ArticleJournal of molecular evolution2005
Comparison of the yeast proteome to other fungal genomes to find core fungal genes.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- First-in-Human Phase 1 Study To Assess Safety, Tolerability, and Pharmacokinetics of a Novel Antifungal Drug, VL-2397, in Healthy Adults.Antimicrobial agents and chemotherapy · 2019Trial
- Transcriptome sequencing reveals iron acquisition-related genes and iron acquisition systems in Auricularia cornea.BMC genomics · 2026Article
- Next-generation antifungal drugs: Mechanisms, efficacy, and clinical prospects.Acta pharmaceutica Sinica. B · 2025Review
- Review
- The Significance of Mono- and Dual-Effective Agents in the Development of New Antifungal Strategies.Chemical biology & drug design · 2025Review
- Inactivation of siderophore iron-chelating moieties by the fungal wheat root symbiont Pyrenophora biseptata.Environmental microbiology reports · 2024Article
- The versatility of the putative transient receptor potential ion channels in regulating the calcium signaling inmSphere · 2023Article
- The cytoplasmic tail of the mechanosensitive channel Pkd2 regulates its internalization and clustering in eisosomes.Journal of cell science · 2023Article
- UFCG: database of universal fungal core genes and pipeline for genome-wide phylogenetic analysis of fungi.Nucleic acids research · 2023Article
- Article
- Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway.Journal of cell science · 2022Article
- Biosynthesis Pathways, Transport Mechanisms and Biotechnological Applications of Fungal Siderophores.Journal of fungi (Basel, Switzerland) · 2021Review
- Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes ofMicroorganisms · 2021Article
- Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis.Molecular biology of the cell · 2019Article
- Population Pharmacokinetic Modeling of VL-2397, a Novel Systemic Antifungal Agent: Analysis of a Single- and Multiple-Ascending-Dose Study in Healthy Subjects.Antimicrobial agents and chemotherapy · 2019Article
- A Loop-Mediated Isothermal Amplification Assay for Rapid Detection ofInternational journal of molecular sciences · 2019Article
- Balancing iron and calcium: Flavin carrier family proteins in Aspergillus fumigatus virulence.Virulence · 2017Article
- Genome-Based Selection and Characterization of Fusarium circinatum-Specific Sequences.G3 (Bethesda, Md.) · 2016Article
- Iron acquisition and oxidative stress response in aspergillus fumigatus.BMC systems biology · 2015Article
- Fungal siderophore metabolism with a focus on Aspergillus fumigatus.Natural product reports · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this research was to search for evolutionarily conserved fungal sequences to test the hypothesis that fungi have a set of core genes that are not found in other organisms, as these genes may indicate what makes fungi different from other organisms. By comparing 6355 predicted or known yeast (Saccharomyces cerevisiae) genes to the genomes of 13 other fungi using Standalone TBLASTN at an e-value <1E-5, a list of 3340 yeast genes was obtained with homologs present in at least 12 of 14 fungal genomes. By comparing these common fungal genes to complete genomes of animals (Fugu rubripes, Caenorhabditis elegans), plants (Arabidopsis thaliana, Oryza sativa), and bacteria (Agrobacterium tumefaciens, Xylella fastidiosa), a list of common fungal genes with homologs in these plants, animals, and bacteria was produced (938 genes), as well as a list of exclusively fungal genes without homologs in these other genomes (60 genes). To ensure that the 60 genes were exclusively fungal, these were compared using TBLASTN to the major sequence databases at GenBank: NR (nonredundant), EST (expressed sequence tags), GSS (genome survey sequences), and HTGS (unfinished high-throughput genome sequences). This resulted in 17 yeast genes with homologs in other fungal genomes, but without known homologs in other organisms. These 17 core, fungal genes were not found to differ from other yeast genes in GC content or codon usage patterns. More intensive study is required of these 17 genes and other common fungal genes to discover unique features of fungi compared to other organisms.
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