ArticleEuropean biophysics journal : EBJ2005
Role of lipid protrusions in the function of interfacial enzymes.
Article in European biophysics journal : EBJ, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Structural aspects and activation mechanism of human secretory group IIA phospholipase.European biophysics journal : EBJ · 2020Article
- Article
- Enzyme-Responsive Liposomes for the Delivery of Anticancer Drugs.Bioconjugate chemistry · 2017Review
- Molecular details of membrane fluidity changes during apoptosis and relationship to phospholipase A(2) activity.Biochimica et biophysica acta · 2013Article
- Neutron reflectivity of supported membranes incorporating terminally anchored polymers: Protrusions vs. blisters.The European physical journal. E, Soft matter · 2013Article
- Lipids, curvature, and nano-medicine.European journal of lipid science and technology : EJLST · 2011Article
- Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments.Biophysical journal · 2009Article
- Amyloid-type fiber formation in control of enzyme action: interfacial activation of phospholipase A2.Biophysical journal · 2008Article
- Colloid adsorption onto responsive membranes.Biophysical journal · 2008Article
- H-ras protein in a bilayer: interaction and structure perturbation.Journal of the American Chemical Society · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secretory phospholipase A(2) (sPLA(2)) is a class of interfacially active enzymes that selectively hydrolyze lipid molecules organized at interfaces like membranes. We present a simple theoretical model that relates the sPLA(2) action to the protrusions of the lipid molecules. The model explains (1) the observed enhancement of enzymatic activity by lipids with flexible, neutral, water-soluble polymers linked to their head groups and (2) the lag-burst kinetics of sPLA(2). It yields qualitative predictions of the effect of the initial composition of the membrane, the molecular weight of the polymer, and the composition of the hydrolysis products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.