ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2005
Genomic cloning and linkage mapping of the Mal d 1 (PR-10) gene family in apple (Malus domestica).
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- FaMYB63 and FvWYRKY75 Activate FvPR10.14 Boosting Strawberry Immunity Against Powdery Mildew.Molecular plant pathology · 2025Article
- Identification of allergenomic signatures in allergic and well-tolerated apple genotypes using LC-MS/MS.Food chemistry. Molecular sciences · 2022Article
- Apple allergy: Causes and factors influencing fruits allergenic properties-Review.Clinical and translational allergy · 2021Review
- Molecular and Immunological Identification of Low Allergenic Fruits among Old and New Apple Varieties.International journal of molecular sciences · 2021Article
- Apple whole genome sequences: recent advances and new prospects.Horticulture research · 2019Review
- Article
- Molecular characteristics and biochemical functions of VpPR10s from Vitis pseudoreticulata associated with biotic and abiotic stresses.International journal of molecular sciences · 2014Article
- Isolation and characterization of a pathogenesis-related protein 10 gene (GmPR10) with induced expression in soybean (Glycine max) during infection with Phytophthora sojae.Molecular biology reports · 2014Article
- Genes responding to water deficit in apple (Malus × domestica Borkh.) roots.BMC plant biology · 2014Article
- A qRT-PCR assay for the expression of all Mal d 1 isoallergen genes.BMC plant biology · 2013Article
- Article
- Genomic organisation of the Mal d 1 gene cluster on linkage group 16 in apple.Molecular breeding : new strategies in plant improvement · 2012Article
- Diversity arrays technology (DArT) markers in apple for genetic linkage maps.Molecular breeding : new strategies in plant improvement · 2012Article
- The Y-segment of novel cold dehydrin genes is conserved and codons in the PR-10 genes are under positive selection in Oxytropis (Fabaceae) from contrasting climates.Molecular genetics and genomics : MGG · 2012Article
- Article
- Over-expression of an FT-homologous gene of apple induces early flowering in annual and perennial plants.Planta · 2010Article
- Characterisation of the Vitis vinifera PR10 multigene family.BMC plant biology · 2010Article
- Scientific Opinion on the assessment of allergenicity of GM plants and microorganisms and derived food and feed.EFSA journal. European Food Safety Authority · 2010Article
- The RNA hydrolysis and the cytokinin binding activities of PR-10 proteins are differently performed by two isoforms of the Pru p 1 peach major allergen and are possibly functionally related.Plant physiology · 2009Article
- Characterization of PR-10 genes from eight Betula species and detection of Bet v 1 isoforms in birch pollen.BMC plant biology · 2009Article
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13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fresh apples can cause birch pollen-related food allergy in northern and central European populations, primarily because of the presence of Mal d 1, the major apple allergen that is cross-reactive to the homologous and sensitizing allergen Bet v 1 from birch. Apple cultivars differ significantly in their allergenicity. Knowledge of the genetic basis of these differences would direct breeding for hypoallergenic cultivars. The PCR genomic cloning and sequencing were performed on two cultivars, Prima and Fiesta, which resulted in 37 different Mal d 1 gDNA sequences. Based on the mapping of sequence-specific molecular markers, these sequences appeared to represent 18 Mal d 1 genes. Sixteen genes were located in two clusters, one cluster with seven genes on linkage group (LG) 13, and the other cluster with nine genes on the homoeologous LG 16. One gene was mapped on LG 6, and one remained unmapped. According to sequence identity, these 18 genes could be subdivided into four subfamilies. Subfamilies I-III had an intron of different size that was subfamily and gene-specific. Subfamily IV consisted of 11 intronless genes. The deduced amino acid sequence identity varied from 65% to 81% among subfamilies, from 82% to 100% among genes within a subfamily, and from 97.5% to 100% among alleles of one gene. This study provides a better understanding of the genetics of Mal d 1 and the basis for further research on the occurrence of allelic diversity among cultivars in relation to allergenicity and their biological functions.
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