ArticleThe Journal of cell biology2005
Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Phosphorylation disrupts the interaction between the intrinsically disordered region of the oncogenic NDRG1 and lipid vesicles.Protein science : a publication of the Protein Society · 2026Article
- SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy.Oncology reports · 2024Article
- Article
- Synaptopodin-2: a potential tumor suppressor.Cancer cell international · 2023Review
- Podocytes and the quest for precision medicines for kidney diseases.Pflugers Archiv : European journal of physiology · 2017Review
- Myopodin methylation is a prognostic biomarker and predicts antiangiogenic response in advanced kidney cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.Nucleic acids research · 2014Article
- Role of AKAP79/150 protein in β1-adrenergic receptor trafficking and signaling in mammalian cells.The Journal of biological chemistry · 2013Article
- Myopodin is an F-actin bundling protein with multiple independent actin-binding regions.Journal of muscle research and cell motility · 2013Article
- Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.Nature communications · 2013Article
- Diagnostic and prognostic utility of methylation and protein expression patterns of myopodin in colon cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.The EMBO journal · 2012Article
- Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization.The EMBO journal · 2012Article
- MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site.PloS one · 2012Article
- FGF23 induces left ventricular hypertrophy.The Journal of clinical investigation · 2011Article
- Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.Neurobiology of disease · 2011Article
- Cardiac Z-disc signaling network.The Journal of biological chemistry · 2011Review
- Synaptopodin family of natively unfolded, actin binding proteins: physical properties and potential biological functions.Biophysical reviews · 2010Review
- 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.Molecular biology of the cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
14-3-3 proteins are phosphoserine/threonine-binding proteins that play important roles in many regulatory processes, including intracellular protein targeting. 14-3-3 proteins can anchor target proteins in the cytoplasm and in the nucleus or can mediate their nuclear export. So far, no role for 14-3-3 in mediating nuclear import has been described. There is also mounting evidence that nuclear import is regulated by the phosphorylation of cargo proteins, but the underlying mechanism remains elusive. Myopodin is a dual-compartment, actin-bundling protein that functions as a tumor suppressor in human bladder cancer. In muscle cells, myopodin redistributes between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. We show that importin alpha binding and the subsequent nuclear import of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin to 14-3-3. These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 binding. They provide a molecular explanation for the phosphorylation-dependent nuclear import of nuclear localization signal-containing cargo proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.