ArticleThe Journal of biological chemistry2005
Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway.
Article in The Journal of biological chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- SS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression.Cell biology and toxicology · 2024Article
- Anti-Inflammatory Properties of Eugenol in Lipopolysaccharide-Induced Macrophages and Its Role in Preventing β-Cell Dedifferentiation and Loss Induced by High Glucose-High Lipid Conditions.Molecules (Basel, Switzerland) · 2023Article
- The STAT3-Regulated Autophagy Pathway in Glioblastoma.Pharmaceuticals (Basel, Switzerland) · 2023Review
- IFNβ-InducedInternational journal of molecular sciences · 2022Article
- PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers.Translational psychiatry · 2020Article
- Diverse effects of interferon alpha on the establishment and reversal of HIV latency.PLoS pathogens · 2020Article
- An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms.Frontiers in immunology · 2019Article
- Transcriptional profile of breast muscle in heat stressed layers is similar to that of broiler chickens at control temperature.Genetics, selection, evolution : GSE · 2017Article
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- Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection.Oncotarget · 2016Article
- Article
- Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis.Clinical and experimental immunology · 2011Article
- The role of nuclear factor κB in the interferon response.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Review
- Immune activation and target organ damage are consequences of hydrodynamic treatment but not delivery of naked siRNAs in mice.Nucleic acid therapeutics · 2011Article
- Marburg virus VP40 antagonizes interferon signaling in a species-specific manner.Journal of virology · 2011Article
- Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.Journal of virology · 2010Article
- Marburg virus evades interferon responses by a mechanism distinct from ebola virus.PLoS pathogens · 2010Article
- Constrained mixture estimation for analysis and robust classification of clinical time series.Bioinformatics (Oxford, England) · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In addition to activating members of the STAT transcription factor family, interferon alpha/beta (IFNalpha/beta) activates the NF-kappaB transcription factor. To determine the role of the Janus tyrosine kinase (JAK)-STAT pathway in NF-kappaB activation by IFN, we examined NF-kappaB activation in JAK1-deficient mutant human fibrosarcoma cells. In wild-type fibrosarcoma cells (2fTGH), IFN activates STAT1, STAT2, and STAT3, as well as NF-kappaB complexes comprised of p50 and p65. In contrast, in JAK1-deficient cells, IFN induces NF-kappaB activation and NF-kappaB dependent gene transcription but does not activate these STAT proteins and has no effect on STAT-dependent gene transcription. Expression of a catalytically inactive TYK2 tyrosine kinase in JAK1-deficient cells, as well as in the highly IFN-sensitive Daudi lymphoblastoid cell line, abrogates NF-kappaB activation by IFN. Moreover, IFN does not promote NF-kappaB activation in TYK2-deficient mutant fibrosarcoma cells. Our results demonstrate a dichotomy between the classical JAK-STAT pathway and the NF-kappaB signaling pathway. In the IFN signaling pathway leading to STAT activation, both JAK1 and TYK2 are essential, whereas NF-kappaB activation requires only TYK2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.