ArticleThe Journal of experimental medicine1992
A role for complement receptor-like molecules in iron acquisition by Candida albicans.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Article
- Ferric reductase related proteins Frp1 and Frp2 mediate reductive heme uptake in the opportunistic pathogen Candida albicans.Journal of inorganic biochemistry · 2026Article
- Genetic Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
- The interactions of Candida albicans with gut bacteria: a new strategy to prevent and treat invasive intestinal candidiasis.Gut pathogens · 2023Review
- Candidalysin Is the Hemolytic Factor ofToxins · 2022Article
- Article
- Regulation of heme utilization and homeostasis in Candida albicans.PLoS genetics · 2022Article
- Cation Transporters ofBiomolecules · 2021Review
- Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans.Cellular microbiology · 2021Article
- Article
- The adaptive response to iron involves changes in energetic strategies in the pathogen Candida albicans.MicrobiologyOpen · 2020Article
- Mechanisms of PathogenicFrontiers in cellular and infection microbiology · 2020Review
- Review
- Identification of cell-associated and secreted serine-type peptidases in multidrug-resistant emergent pathogens belonging to the Candida haemulonii complex.Folia microbiologica · 2019Article
- Iron at the Centre ofFrontiers in cellular and infection microbiology · 2018Review
- Metals in fungal virulence.FEMS microbiology reviews · 2018Review
- Article
- Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens.FEMS yeast research · 2015Review
- Candida albicans specializations for iron homeostasis: from commensalism to virulence.Current opinion in microbiology · 2013Article
- Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans.Frontiers in cellular and infection microbiology · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Candida albicans, an opportunistic fungal pathogen of humans, is dependent upon iron for growth. Consequently, human serum inhibits C. albicans growth due to the presence of high affinity iron-binding proteins that sequester serum iron, making it unavailable for use by the organism. We report that in the inhibitory environment of human serum, the growth of C. albicans can be restored by the addition of exogenous hemoglobin or heme, but not by protoporphyrin IX, the heme precursor that does not contain iron. We further report that C. albicans can utilize cell surface proteins that are homologues of the mammalian complement receptors (CR) to rosette complement-coated red blood cells (RBC) and obtain RBC-derived iron for growth. The ability of Candida to acquire RBC-derived iron under these conditions is dependent upon Candida-RBC rosetting mediated by CR-like molecules. Unopsonized RBC do not support Candida growth in serum, and restoration of Candida growth in serum by complement-opsonized RBC is inhibited by monoclonal antibodies to the human CR type 3 (CR3). In addition, activation of the human alternative pathway of complement by Candida leads to "bystander" deposition of C3 fragments on the surface of autologous, unopsonized RBC, generating the ligands necessary for Candida-RBC rosetting. These results suggest that C. albicans has evolved a unique strategy for acquiring iron from the host, which exploits the host complement system, and which may contribute to the pathogenic potential of the organism.
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