ReviewLipids in health and disease2005
Role of cholesterol in parasitic infections.
Review in Lipids in health and disease, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- Serum lipids and lipoproteins in malaria--a systematic review and meta-analysis.Malaria journal · 2013Pooled it
- Article
- Article
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- Mass Spectrometry Imaging of Lipid and Metabolite Distributions in Cysts ofJournal of the American Society for Mass Spectrometry · 2025Article
- Genome of the invasive North American Haemaphysalis longicornis tick as a template for bovine anti-tick vaccine discovery.BMC genomics · 2025Article
- Traditional Maasai Dietary Practices and Their Inapplicability to Modern Carnivore Diets: A Narrative Review.Cureus · 2025Review
- The Influence of the ProtozoanInternational journal of molecular sciences · 2024Review
- Harnessing cholesterol uptake of malaria parasites for therapeutic applications.EMBO molecular medicine · 2024Article
- Correlation between Melatonin and Colostral Regulatory T Cells inBiomolecules · 2024Article
- Function and regulation of a steroidogenic CYP450 enzyme in the mitochondrion of Toxoplasma gondii.PLoS pathogens · 2023Article
- Lipid Accumulation inMicroorganisms · 2023Article
- Identifying hepatic genes regulating the ovine response to gastrointestinal nematodes using RNA-Sequencing.Frontiers in genetics · 2023Article
- A bloody interaction: plasma proteomics reveals gilthead sea bream (Sparus aurata) impairment caused by Sparicotyle chrysophrii.Parasites & vectors · 2022Article
- A myxozoan genome reveals mosaic evolution in a parasitic cnidarian.BMC biology · 2022Article
- Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking DuringFrontiers in cellular and infection microbiology · 2022Article
- Article
- The determinants of lipid profiles in early adolescence in a Ugandan birth cohort.Scientific reports · 2021Article
- Exosomal microRNA let-7-5p fromMicroorganisms · 2021Article
- Management of Antiretroviral Therapy with Boosted Protease Inhibitors-Darunavir/Ritonavir or Darunavir/Cobicistat.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The requirement of cholesterol for internalization of eukaryotic pathogens like protozoa (Leishmaniasis, Malaria and Toxoplasmosis) and the exchange of cholesterol along with other metabolites during reproduction in Schistosomes (helminths) under variable circumstances are poorly understood. In patients infected with some other helminthes, alterations in the lipid profile have been observed. Also, the mechanisms involved in lipid changes especially in membrane proteins related to parasite infections remain uncertain. Present review of literature shows that parasites induce significant changes in lipid parameters, as has been shown in the in vitro study where substitution of serum by lipid/cholesterol in medium and in experimental models (in vivo). Thus changes in lipid profile occur in patients having active infections with most of the parasites. Membrane proteins are probably involved in such reactions. All parasites may be metabolising cholesterol, but the exact relationship with pathogenic mechanism is not clear. So far, studies suggest that there may be some factors or enzymes, which allow the parasite to breakup and consume lipid/cholesterol. Further studies are needed for better understanding of the mechanisms involved in vivo. The present review analysis the various studies till date and the role of cholesterol in pathogenesis of different parasitic infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.