ArticleNeural computation2005
Gain control by concerted changes in I(A) and I(H) conductances.
Article in Neural computation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
- Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.Neuroscience · 2016Article
- Article
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
- Article
- Mechanisms of gain control by voltage-gated channels in intrinsically-firing neurons.PloS one · 2015Article
- The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons.Journal of neurophysiology · 2014Article
- Article
- Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate.Frontiers in neural circuits · 2013Article
- Tuning low-voltage-activated A-current for silent gain modulation.Neural computation · 2012Article
- Functional maps within a single neuron.Journal of neurophysiology · 2012Review
- Ionic current correlations underlie the global tuning of large numbers of neuronal activity attributes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ca²⁺/cAMP-sensitive covariation of I(A) and I(H) voltage dependences tunes rebound firing in dopaminergic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuromodulation independently determines correlated channel expression and conductance levels in motor neurons of the stomatogastric ganglion.Journal of neurophysiology · 2012Article
- Conductance ratios and cellular identity.PLoS computational biology · 2010Article
- Intrinsic membrane properties of pre-oromotor neurons in the intermediate zone of the medullary reticular formation.Neuroscience · 2010Article
- Neuromodulators, not activity, control coordinated expression of ionic currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
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1 author.
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Abstract
Stability of intrinsic electrical activity and modulation of input-output gain are both important for neuronal information processing. It is therefore of interest to define biologically plausible parameters that allow these two features to coexist. Recent experiments indicate that in some biological neurons, the stability of spontaneous firing can arise from coregulated expression of the electrophysiologically opposing I(A) and I(H) currents. Here, I show that such balanced changes in I(A) and I(H) dramatically alter the slope of the relationship between the firing rate and driving current in a Hodgkin-Huxley-type model neuron. Concerted changes in I(A) and I(H) can thus control neuronal gain while preserving intrinsic activity.
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