ArticleBritish journal of pharmacology2005
Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Pharmacokinetics and pharmacodynamics of propiverine in children aged between 5 and 10 years with symptoms of overactive bladder.Clinical pharmacokinetics · 2010Trial
- Oral absorption of propiverine solution and of the immediate and extended release dosage forms: influence of regioselective intestinal elimination.European journal of clinical pharmacology · 2008Trial
- Comparisons of urinary bladder responses to common antimuscarinics reveals unique effects of darifenacin.Frontiers in physiology · 2025Article
- Article
- Factors Associated with Decisions for Initial Dosing, Up-Titration of Propiverine and Treatment Outcomes in Overactive Bladder Syndrome Patients in a Non-Interventional Setting.Journal of clinical medicine · 2021Article
- A Novel in situ Approach to Studying Detrusor Smooth Muscle Cells in Mice.Scientific reports · 2020Article
- Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.Acta pharmacologica Sinica · 2014Article
- Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms.Clinical drug investigation · 2013Review
- Functional investigation of β-adrenoceptors in human isolated detrusor focusing on the novel selective β3-adrenoceptor agonist KUC-7322.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- The muscarinic receptor antagonist propiverine exhibits α(1)-adrenoceptor antagonism in human prostate and porcine trigonum.World journal of urology · 2011Article
- Efficacy of propiverine ER with or without α-blockers related to maximum urinary flow rate in adult men with OAB: results of a 12-week, multicenter, non-interventional study.World journal of urology · 2011Article
- Anticholinergic effects of cis- and trans-isomers of two metabolites of propiverine.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Urothelial effects of oral agents for overactive bladder.Current urology reports · 2008Review
- Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue.Pflugers Archiv : European journal of physiology · 2008Article
- Electrophysiological profile of propiverine--relationship to cardiac risk.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-type Ca2+ currents and Ca2+ transients in murine urinary bladder myocytes.The Journal of pharmacology and experimental therapeutics · 2008Article
- Does ivabradine exhibit a role in the reduction of bladder overactivity?International urology and nephrology · 2008Article
- Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
- Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- Effect of rilmakalim on detrusor contraction in the presence and absence of urothelium.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Besides its antimuscarinic effects, propiverine may possess an additional mode of action. We compared the effects of propiverine, three of its metabolites (M-5, M-6, M-14) and atropine in human, pig and mouse urinary bladder preparations in order to elucidate the nature of a possible additional mode of action. 2. Like the parent compound, M-5, M-6 and M-14 reduced to variable degrees the contractions elicited by electric field stimulation (EFS) of isolated, urothelium-denuded detrusor strips. In mouse the atropine-resistant and therefore the nonadrenergic, noncholinergic component of contractile response to EFS was reduced by M-5, M-14 and propiverine, but was hardly affected by M-6. 3. Atropine, propiverine and M-6 significantly shifted the cumulative concentration-response curves for carbachol (CCh) to higher concentrations. Atropine and M-6 did not affect the maximum tension induced by CCh. Propiverine, M-5 and M-14 reduced the maximum CCh effect, suggesting at least one additional mode of action. This pattern of response was observed in all the three species, albeit with some differences in sensitivity to the various agents. 4. In freshly isolated human detrusor smooth muscle cells, propiverine and M-14 inhibited the nifedipine-sensitive L-type calcium current (I(Ca)) in a concentration-dependent manner. In contrast, the effects of M-5 and M-6 on I(Ca) were insignificant in the concentration range examined. 5. The investigated responses to propiverine and its metabolites suggest that impairment of maximum CCh-induced contractions is due to strong effect on I(Ca) and that this may be associated with the presence of the aliphatic side chain.
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