ArticleNature neuroscience2005
XTRPC1-dependent chemotropic guidance of neuronal growth cones.
Article in Nature neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 162 citations in OpenAlex.
- Corneal Sensory Receptors and Pharmacological Therapies to Modulate Ocular Pain.International journal of molecular sciences · 2025Review
- A spatially specified systems pharmacology therapy for axonal recovery after injury.Frontiers in pharmacology · 2023Article
- Signal amplification in growth cone gradient sensing by a double negative feedback loop among PTEN, PI(3,4,5)PMolecular and cellular neurosciences · 2022Article
- Function of the PorcineCells · 2021Article
- TRPV2 interacts with actin and reorganizes submembranous actin cytoskeleton.Bioscience reports · 2020Article
- TRPC6-Mediated CaNeurochemical research · 2020Article
- How TRPC Channels Modulate Hippocampal Function.International journal of molecular sciences · 2020Review
- TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.Cells · 2020Article
- TRPC5 regulates axonal outgrowth in developing retinal ganglion cells.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- From Neural Tube Formation Through the Differentiation of Spinal Cord Neurons: Ion Channels in Action During Neural Development.Frontiers in molecular neuroscience · 2020Article
- Trpc1 as the Missing Link Between the Bmp and CaScientific reports · 2019Article
- TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.PLoS biology · 2019Article
- TRPC3 Is Dispensable for β-Alanine Triggered Acute Itch.Scientific reports · 2017Article
- Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Review
- Expression of TRPC6 and BDNF in Cortical Lesions From Patients With Focal Cortical Dysplasia.Journal of neuropathology and experimental neurology · 2016Article
- TRPC Channels: Prominent Candidates of Underlying Mechanism in Neuropsychiatric Diseases.Molecular neurobiology · 2016Review
- Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.Molecular and cellular biology · 2015Article
- Ca(2+) signaling initiated by canonical transient receptor potential channels in dendritic development.Neuroscience bulletin · 2015Review
- Microtopographical features generated by photopolymerization recruit RhoA/ROCK through TRPV1 to direct cell and neurite growth.Biomaterials · 2015Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) belong to a superfamily of Ca2+-permeable, receptor-operated channels that have important roles in sensing and responding to changes in the local environment. Here we report that XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to microscopic gradients of netrin-1, brain-derived neurotrophic factor and myelin-associated glycoprotein, but not to semaphorin 3A. Furthermore, XTRPC1 is required for midline guidance of axons of commissural interneurons in the developing Xenopus spinal cord. Thus, members of the TRPC family may serve as a key mediator for the Ca2+ influx that regulates axon guidance during development and inhibits axon regeneration in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.