ArticleGenes & development2005
Lozenge directly activates argos and klumpfuss to regulate programmed cell death.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Knockout of a single Pax6 gene (toy but not ey) leads to compound eye deficiency and small head in honeybees.Communications biology · 2024Article
- Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc.Nature communications · 2024Article
- Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids.Journal of innate immunity · 2022Article
- Semper's cells in the insect compound eye: Insights into ocular form and function.Developmental biology · 2021Review
- Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila.The EMBO journal · 2019Article
- Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye.PLoS genetics · 2018Article
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- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- The RUNX family: developmental regulators in cancer.Nature reviews. Cancer · 2015Review
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression.Developmental biology · 2014Article
- The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.Developmental biology · 2014Article
- Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila.Cell reports · 2013Article
- Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3.Histochemistry and cell biology · 2013Article
- Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.Development (Cambridge, England) · 2013Article
- Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Identification of RUNX3 as a component of the MST/Hpo signaling pathway.Journal of cellular physiology · 2012Article
- The lens in focus: a comparison of lens development in Drosophila and vertebrates.Molecular genetics and genomics : MGG · 2011Review
- Computer simulation of cellular patterning within the Drosophila pupal eye.PLoS computational biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.