ArticleGenetics2005
Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Genetic basis of Fusarium ear rot resistance and productivity traits in a heterozygous multi-parent recombinant inbred intercross (RIX) maize population.BMC plant biology · 2025Article
- A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.EBioMedicine · 2024Article
- Genetic architecture of the acute and persistent immune cell response after radiation exposure.Cell genomics · 2023Article
- Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection.International journal of molecular sciences · 2023Article
- Review
- Genetic and immunological contributors to virus-induced paralysis.Brain, behavior, & immunity - health · 2021Article
- Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions.International journal of molecular sciences · 2021Article
- Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice.NPJ vaccines · 2021Article
- Antipsychotic Behavioral Phenotypes in the Mouse Collaborative Cross Recombinant Inbred Inter-Crosses (RIX).G3 (Bethesda, Md.) · 2020Article
- Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies.Scientific reports · 2020Article
- Mouse Systems Genetics as a Prelude to Precision Medicine.Trends in genetics : TIG · 2020Review
- gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population.G3 (Bethesda, Md.) · 2018Article
- Acyloxyacyl hydrolase modulates pelvic pain severity.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Joint Analysis of Strain and Parent-of-Origin Effects for Recombinant Inbred Intercrosses Generated from Multiparent Populations with the Collaborative Cross as an Example.G3 (Bethesda, Md.) · 2018Article
- Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures.Environmental health perspectives · 2017Review
- Powerful decomposition of complex traits in a diploid model.Nature communications · 2016Article
- Genetics of aging bone.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Integration of genome-wide association and extant brain expression QTL identifies candidate genes influencing prepulse inhibition in inbred F1 mice.Genes, brain, and behavior · 2016Article
- Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We describe a new approach, called recombinant inbred intercross (RIX) mapping, that extends the power of recombinant inbred (RI) lines to provide sensitive detection of quantitative trait loci (QTL) responsible for complex genetic and nongenetic interactions. RIXs are generated by producing F1 hybrids between all or a subset of parental RI lines. By dramatically extending the number of unique, reproducible genomes, RIXs share some of the best properties of both the parental RI and F2 mapping panels. These attributes make the RIX method ideally suited for experiments requiring analysis of multiple parameters, under different environmental conditions and/or temporal sampling. However, since any pair of RIX genomes shares either one or no parental RIs, this cross introduces an unusual population structure requiring special computational approaches for analysis. Herein, we propose an efficient statistical procedure for QTL mapping with RIXs and describe a novel empirical permutation procedure to assess genome-wide significance. This procedure will also be applicable to diallel crosses. Extensive simulations using strain distribution patterns from CXB, AXB/BXA, and BXD mouse RI lines show the theoretical power of the RIX approach and the analysis of CXB RIXs demonstrates the limitations of this procedure when using small RI panels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.