ArticleJournal of the American Society for Mass Spectrometry2005
The structure of gas-phase bradykinin fragment 1-5 (RPPGF) ions: an ion mobility spectrometry and H/D exchange ion-molecule reaction chemistry study.
Article in Journal of the American Society for Mass Spectrometry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Capillary Vibrating Sharp-Edge Spray Ionization Augments Field-Free Ionization Techniques to Promote Conformer Preservation in the Gas-Phase for Intractable Biomolecular Ions.The journal of physical chemistry. B · 2022Article
- THE IMS PARADOX: A PERSPECTIVE ON STRUCTURAL ION MOBILITY-MASS SPECTROMETRY.Mass spectrometry reviews · 2021Review
- Towards unsupervised polyaromatic hydrocarbons structural assignment from SA-TIMS-FTMS data.International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry · 2015Article
- Theoretical predictor for candidate structure assignment from IMS data of biomolecule-related conformational space.International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry · 2015Article
- Linking molecular models with ion mobility experiments. Illustration with a rigid nucleic acid structure.Journal of mass spectrometry : JMS · 2015Article
- An IMS-IMS threshold method for semi-quantitative determination of activation barriers: Interconversion of prolineInternational journal of mass spectrometry · 2015Article
- Combined use of post-ion mobility/collision-induced dissociation and chemometrics for b fragment ion analysis.Journal of the American Society for Mass Spectrometry · 2013Article
- Conformation types of ubiquitin [M+8H]8+ Ions from water:methanol solutions: evidence for the N and A States in aqueous solution.The journal of physical chemistry. B · 2012Article
- A Study of Ion-Neutral Collision Cross Section Values for Low Charge States of Peptides, Proteins, and Peptide/Protein Complexes.International journal of mass spectrometry · 2010Article
- Identification and counting of carbonyl and hydroxyl functionalities in protonated bifunctional analytes by using solution derivatization prior to mass spectrometric analysis via ion-molecule reactions.Journal of the American Society for Mass Spectrometry · 2010Article
- Structural characterization of phospholipids and peptides directly from tissue sections by MALDI traveling-wave ion mobility-mass spectrometry.Analytical chemistry · 2010Article
- Factors that influence helical preferences for singly charged gas-phase peptide ions: the effects of multiple potential charge-carrying sites.The journal of physical chemistry. B · 2010Article
- Evidence of diketopiperazine and oxazolone structures for HA b2+ ion.Journal of the American Chemical Society · 2009Article
- A mechanistic study of the H/D exchange reactions of protonated arginine and arginine-containing di- and tripeptides.Journal of the American Society for Mass Spectrometry · 2009Article
- The contributions of molecular framework to IMS collision cross-sections of gas-phase peptide ions.Journal of the American Society for Mass Spectrometry · 2009Article
- A novel approach to collision-induced dissociation (CID) for ion mobility-mass spectrometry experiments.Journal of the American Society for Mass Spectrometry · 2009Article
- Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange.Rapid communications in mass spectrometry : RCM · 2008Article
- Detection of oligonucleotide gas-phase conformers: H/D exchange and ion mobility as complementary techniques.Journal of the American Society for Mass Spectrometry · 2008Article
- A collision cross-section database of singly-charged peptide ions.Journal of the American Society for Mass Spectrometry · 2007Article
- Comparative studies of 193-nm photodissociation and TOF-TOFMS analysis of bradykinin analogues: the effects of charge site(s) and fragmentation timescales.Journal of the American Society for Mass Spectrometry · 2006Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Ion mobility-mass spectrometry (IM-MS) data is interpreted as evidence that gas-phase bradykinin fragment 1-5 (BK1-5, RPPGF) [M + H](+) ions exist as three distinct structural forms, and the relative abundances of the structural forms depend on the solvent used to prepare the matrix-assisted laser desorption ionization (MALDI) samples. Samples prepared from organic rich solvents (90% methanol/10% water) yield ions having an ion mobility arrival-time distribution (ATD) that is dominated by a single peak; conversely, samples prepared using mostly aqueous solvents (10% methanol/90% water) yield an ATD composed of three distinct peaks. The BK1-5 [M + H](+) ions were also studied by gas-phase hydrogen/deuterium (H/D) exchange ion-molecule reactions and this data supports our interpretation of the IM-MS data. Plausible structures for BK1-5 ions were generated by molecular dynamics (MD). Candidate MD-generated structures correlated to measured cross-sections suggest a compact conformer containing a beta-turn whereas a more extended, open form does not contain such an interaction. This study illustrates the importance of intra-molecular interactions in the stabilization of the gas-phase ions, and these results clearly illustrate that solution-phase parameters (i.e., MALDI sample preparation) greatly influence the structures of gas-phase ions.
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Registered trials
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