Evidence map›Paper›PMID 15876347›Full record

Trial reportBMC pediatrics2005

Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076].

Joanne M Langley, Michael B Smith, John C LeBlanc, Heather Joudrey, Cecil R Ojah, Paul Pianosi

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02724761 (Prophylactic Racemic Epinephrine for the Prevention of Dysphagia in Patients Undergoing Anterior Cervical Discectomy and Fusion), which is not on this map. Cited by 14 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 6 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02724761 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Prophylactic Racemic Epinephrine for the Prevention of Dysphagia in Patients Undergoing Anterior Cervical Discectomy and Fusion: A Randomized Control Trial

TypeinterventionalSponsorAndrew ChungRan2016 to 2018Enrolled90ConditionsDysphagia, Dysphonia, Postoperative PainArmsRacemic Epinephrine, Placebo (for racemic epinephrine)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Bronchodilators for bronchiolitis.The Cochrane database of systematic reviews · 2014
    Pooled it
  4. Epinephrine for bronchiolitis.The Cochrane database of systematic reviews · 2011
    Pooled it
  5. Bronchiolitis.BMJ clinical evidence · 2011
    Pooled it
  6. Bronchiolitis.BMJ clinical evidence · 2007
    Pooled it
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Safety of epinephrine for anaphylaxis in the emergency setting.World journal of emergency medicine · 2013
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Joanne M LangleyClinical Trials Research Centre, Dalhousie University, Halifax, Canada. joanne.langley@dal.ca
Michael B Smith
John C LeBlanc
Heather Joudrey
Cecil R Ojah
Paul Pianosi
Dalhousie University · CACraigavon Area Hospital · GBMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchiolitis is the most common cause of lower respiratory tract illness in infancy, and hospital admission rates appear to be increasing in Canada and the United States. Inhaled beta agonists offer only modest short-term improvement. Trials of racemic epinephrine have shown conflicting results. We sought to determine if administration of racemic epinephrine during hospital stay for bronchiolitis improved respiratory distress, was safe, and shortened length of stay.

methodsThe study was a randomized, double-blind controlled trial of aerosolized racemic epinephrine compared to salbutamol every one to 4 hours in previously well children aged 6 weeks to < or = 2 years of age hospitalized with bronchiolitis. The primary outcome was symptom improvement as measured by the Respiratory Distress Assessment Instrument (RDAI); secondary outcomes were length of stay in hospital, adverse events, and report of symptoms by structured parental telephone interview one week after discharge.

results62 children with a mean age of 6.4 months were enrolled; 80% of children had Respiratory Syncytial Virus (RSV). Racemic epinephrine resulted in significant improvement in wheezing and the total RDAI score on day 2 and over the entire stay (p < 0.05). The mean LOS in the epinephrine arm was 2.6 days (95% CI 2, 3.2) v. 3.4 days in those in the salbutamol group (95% CI 2.6, 4.2) (p > 0.05). Adverse events were not significantly different in the two arms. At one week post-discharge, over half of parents reported that their child still had a respiratory symptom and 40% had less than normal feeding.

conclusionRacemic epinephrine relieves respiratory distress in hospitalized infants with bronchiolitis and is safe but does not abbreviate hospital stay. Morbidity associated with bronchiolitis as identified by parents persists for at least one week after hospital discharge in most infants.

Indexed as

RacepinephrineAdministration, InhalationAlbuterolBronchiolitisBronchodilator AgentsChild, PreschoolDouble-Blind MethodEpinephrineHumansInfantLength of StayRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsSeverity of Illness IndexStereoisomerismTreatment OutcomeAlbuterolBronchodilator AgentsEpinephrineRacepinephrine

Identifiers

PMID15876347
PMCPMC1142326
OpenAlexW1873334451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.