ArticleInfection and immunity1992
Molecular characterization of an RTX toxin determinant from Actinobacillus suis.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Review
- Genome Sequence of Actinobacillus suis Type Strain ATCC 33415T.Genome announcements · 2014Article
- Simultaneous detection of antibodies against Apx toxins ApxI, ApxII, ApxIII, and ApxIV in pigs with known and unknown Actinobacillus pleuropneumoniae exposure using a multiplexing liquid array platform.Clinical and vaccine immunology : CVI · 2014Article
- RTX proteins: a highly diverse family secreted by a common mechanism.FEMS microbiology reviews · 2010Review
- Insight into siderophore-carrying peptide biosynthesis: enterobactin is a precursor for microcin E492 posttranslational modification.Antimicrobial agents and chemotherapy · 2007Article
- Characterization of PaxA and its operon: a cohemolytic RTX toxin determinant from pathogenic Pasteurella aerogenes.Infection and immunity · 2000Article
- Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.Microbiology and molecular biology reviews : MMBR · 1998Review
- Detection of RTX toxin genes in gram-negative bacteria with a set of specific probes.Applied and environmental microbiology · 1997Article
- Actinobacillus suis strains isolated from healthy and diseased swine are clonal and carry apxICABDvar. suis and apxIICAvar. suis toxin genes.Journal of clinical microbiology · 1997Article
- Characterization of an RTX toxin from enterohemorrhagic Escherichia coli O157:H7.Infection and immunity · 1996Article
- Molecular analysis of a metalloprotease from Proteus mirabilis.Journal of bacteriology · 1995Article
- Production of Apx toxins by field strains of Actinobacillus pleuropneumoniae and Actinobacillus suis.Infection and immunity · 1994Article
- Molecular analysis of the leukotoxin determinants from Pasteurella haemolytica serotypes 1 to 16.Infection and immunity · 1993Article
- ABC transporters: bacterial exporters.Microbiological reviews · 1993Review
- Structural analysis of the Actinobacillus pleuropneumoniae-RTX-toxin I (ApxI) operon.Infection and immunity · 1993Article
- Molecular characterization of a leukotoxin gene from a Pasteurella haemolytica-like organism, encoding a new member of the RTX toxin family.Infection and immunity · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RTX cytolysins are a family of calcium-dependent, pore-forming, secreted toxins found in a variety of gram-negative bacteria. The prototypical member of this family is the alpha-hemolysin of Escherichia coli. The RTX genetic determinants from seven members of the family Pasteurellaceae, Pasteurella haemolytica, Actinobacillus actinomycetemcomitans, and A. pleuropneumoniae serotypes 1,5,7, and 9 were previously cloned and sequenced. Using the leukotoxin determinant from P. haemolytica serotype A1 as a probe, we detected the presence of RTX-type determinants in Actinobacillus suis, A. equuli, and A. lignieresii of the family Pasteurellaceae. All three species elaborate proteins of approximately 104 to 110 kDa that are recognized by polyclonal antisera against the 104-kDa hemolysin of A. pleuropneumoniae serotype 1. An RTX determinant of A. suis isolate 3714 was cloned and sequenced and was found to be almost identical to the RTX determinant of A. pleuropneumoniae serotypes 5 and 9. In addition, the determinant is not composed of four contiguous genes, as had been reported for most other RTX determinants; instead, the genes encoding the two proteins responsible for secretion of the toxin are at a locus distinct from that containing the toxin structural and activation genes.
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