ArticlePsychopharmacology2005
Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Characteristics of olfactory ensheathing cells and microarray analysis in Tupaia belangeri (Wagner, 1841).Molecular medicine reports · 2019Article
- Chronic psychosocial stressors in adulthood: Studies in mice, rats and tree shrews.Neurobiology of stress · 2017Review
- Effects of the Synthetic Neurosteroid: 3β-Methoxypregnenolone (MAP4343) on Behavioral and Physiological Alterations Provoked by Chronic Psychosocial Stress in Tree Shrews.The international journal of neuropsychopharmacology · 2016Article
- Innovative drugs to treat depression: did animal models fail to be predictive or did clinical trials fail to detect effects?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Tree shrews (Tupaia belangeri) exhibit novelty preference in the novel location memory task with 24-h retention periods.Frontiers in psychology · 2014Article
- Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.PloS one · 2013Article
- A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment.The international journal of neuropsychopharmacology · 2011Article
- The development of behavioral and endocrine abnormalities in rats after repeated exposure to direct and indirect stress.Neuropsychiatric disease and treatment · 2008Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
rationaleSubstance P and its preferred receptor, the neurokinin 1 receptor (NK(1)R), have been proposed as possible targets for new antidepressant therapies, although results of a recently completed phase III trial failed to demonstrate that the NK(1)R antagonist MK-869 is more effective than placebo in the treatment of depression.
methodsIn the present study, we compared the effects of the NK(1)R antagonist L-760735 with the tricyclic antidepressant clomipramine on endocrine and behavioral parameters in chronically stressed tree shrews. Animals were subjected to a 7-day period of psychosocial stress before receiving daily oral administration of L-760735 (10 mg/kg/day) or clomipramine (50 mg/kg/day). The psychosocial stress continued throughout the treatment period of 21 days. Daily morning urine was collected to measure cortisol and norepinephrine levels. All animals were videotaped daily and three types of behavior were analyzed.
resultsChronic psychosocial stress resulted in a significant increase of urinary cortisol and norepinephrine concentrations. Moreover, stressed animals displayed decreased marking behavior and locomotor activity, while grooming remained unaffected. Neither treatment with clomipramine nor L-760735 was able to normalize the stress-induced elevation of cortisol or norepinephrine. On the behavioral parameters, L-760735 had a time-dependent restorative influence on marking behavior close to normal levels, without affecting locomotor activity. Grooming behavior was significantly increased by the 3 weeks of drug treatment.
conclusionsThese results suggest that L-760735 was able to counteract certain stress-induced behavioral alterations in an animal model of depression.
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