ArticleGenes and immunity2005
Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene.
Article in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 109 citations in OpenAlex.
- Immunoglobulin Disorders and the Oral Cavity: A Narrative Review.Journal of clinical medicine · 2022Review
- A View on Polymerase Chain Reaction as an Outstanding Molecular Diagnostic Technique in Periodontology.BioMed research international · 2021Review
- Epigenetic findings in periodontitis in UK twins: a cross-sectional study.Clinical epigenetics · 2019Article
- Association of vitamin D binding protein and vitamin D receptor gene polymorphisms in Iranian patients with chronic periodontitis.Odontology · 2019Article
- TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals.PeerJ · 2019Article
- Review
- Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response.JDR clinical and translational research · 2018Article
- B10 Cells Alleviate Periodontal Bone Loss in Experimental Periodontitis.Infection and immunity · 2017Article
- Role of Thr399Ile and Asp299Gly polymorphisms of toll-like receptor-4 gene in acute dental abscess.Journal of clinical and experimental dentistry · 2017Article
- Alveolar bone loss in relation to toll-like receptor 4 and 9 genotypes and Porphyromonas gingivalis carriage.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania.Autoimmune and infectious diseases : open access · 2016Article
- Article
- Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis.Journal of periodontal research · 2015Article
- Toll-like receptor 4 gene polymorphism is associated with chronic periodontitis.International journal of clinical and experimental medicine · 2015Article
- RANKL expression in periodontal disease: where does RANKL come from?BioMed research international · 2014Review
- A novel porcine acellular dermal matrix scaffold used in periodontal regeneration.International journal of oral science · 2013Article
- Role of MyD88-dependent and MyD88-independent signaling in Porphyromonas gingivalis-elicited macrophage foam cell formation.Molecular oral microbiology · 2013Article
- Effect of gene polymorphisms on periodontal diseases.Indian journal of human genetics · 2012Article
- Analysis of association between TLR-4 Asp299Gly and Thr399Ile gene polymorphisms and chronic periodontitis in a sample of south Indian population.Journal of Indian Society of Periodontology · 2011Article
- Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese.The open dentistry journal · 2011Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is an inflammatory disease affecting the connective tissue surrounding the teeth leading to tooth loss. Pathogens associated with periodontitis interact with Toll-like receptors (TLRs) to induce cytokines causing and aggravating disease. We screened 197 individuals suffering from generalized periodontitis for the presence of Asp299Gly and Thr399Ile of TLR-4 as well as Arg753Gln of TLR-2 in comparison to matched controls. Single-nucleotide polymorphisms (SNPs) of TLR-4 were elevated among patients (odd's ratio 3.650, 95% CI 1.573-8.467, P < or = 0.0001), while no difference was observed for TLR-2. TLR-4 SNPs were correlated with chronic periodontitis (odd's ratio 5.562, 95% CI 2.199-14.04, P < or = 0.0001), but not with aggressive periodontitis. This observation was confirmed employing a group of periodontally healthy probands over 60 years of age. These data demonstrate that genetic variants of TLR-4 may act as risk factors for the development of generalized chronic periodontitis in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.