ArticleJournal of clinical microbiology2005
Efficiency of the ortho VITROS assay for detection of hepatitis C virus-specific antibodies increased by elimination of supplemental testing of samples with very low sample-to-cutoff ratios.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Is Geenius HCV Supplemental Assay an Alternative to HCV Confirmatory Western Blot INNO-LIA HCV Score in Repeatedly Reactive Blood Donations After First Line Screening?Journal of clinical laboratory analysis · 2026Article
- Evaluation of Two-Assay Serological Testing Strategies for Anti-HCV Screening in Italian Populations: A Dual Screening Approach.Diagnostics (Basel, Switzerland) · 2024Article
- The role of a two-assay serological testing strategy for anti-HCV screening in low-prevalence populations.Scientific reports · 2021Article
- Retrospective analysis on the diagnostic performances and signal-to-cut-off ratios of the Elecsys Anti-HCV II assay.Journal of clinical laboratory analysis · 2018Article
- Evaluation of Quantitative Real-Time PCR as a Hepatitis C Virus Supplementary Test After RIBA Discontinuation.Journal of clinical laboratory analysis · 2016Article
- Hepatitis C virus: Screening, diagnosis, and interpretation of laboratory assays.Asian journal of transfusion science · 2014Review
- Determining immunoassay cutoff value using Western blot results to predict hepatitis C infection in blood donors with low-titer anti-HCV reactivity.Folia microbiologica · 2013Article
- Role of signal-to-cutoff ratios in hepatitis C virus antibody detection.Clinical and vaccine immunology : CVI · 2012Article
- Comparison of serial Hepatitis C virus detection in samples submitted through serology for reflex confirmation versus samples directly submitted for quantitation.Journal of clinical microbiology · 2011Article
- Anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia.The Korean journal of internal medicine · 2009Article
- Clinical performance evaluation of four automated chemiluminescence immunoassays for hepatitis C virus antibody detection.Journal of clinical microbiology · 2008Article
- Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV.The Journal of infectious diseases · 2008Article
- Evaluation of the Ortho-Clinical Diagnostics Vitros ECi Anti-HCV test: comparison with three other methods.Journal of clinical laboratory analysis · 2007Article
- Discordant results of two automated assays for detection of hepatitis C virus-specific antibody.Journal of clinical microbiology · 2006Article
- Role of signal-to-cut-off ratios of anti-hepatitis C virus antibody by enzyme immunoassays along with ID-NAT for screening of whole blood donors in India.Asian journal of transfusion scienceArticle
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5 authors.
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Abstract
The clinical significance of specimens with low sample-to-cutoff (S/Co) ratios in the Ortho VITROS chemiluminescence assay (CIA) for detection of antibodies to hepatitis C virus (HCV) was evaluated. In one study of 482 CIA-reactive samples, none of the 83 samples with S/Co ratios of < 5 was HCV RNA positive. In a subsequent study, 332 samples with S/Co ratios of between 1 and 20 were tested with the recombinant immunoblot assay (RIBA). None of the 163 samples with S/Co ratios of < 5 was RIBA positive, 83% were RIBA negative, and 28 samples (18%) were RIBA indeterminate. HCV RNA and/or clinical evidence of hepatitis was not found in the 27 indeterminate cases examined. These results show that over 99% of samples with very low S/Co ratios (< or = 5) have no evidence of HCV infection. Therefore, we suggest that the HCV antibody testing algorithm for the VITROS assay might be modified to eliminate supplemental testing of samples with very low S/Co ratios.
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