ArticleJournal of clinical microbiology2005
Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Global H. pylori recurrence, recrudescence, and re-infection status after successful eradication in pediatric patients: a systematic review and meta-analysis.Journal of gastroenterology · 2024Pooled it
- The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood.Pediatrics international : official journal of the Japan Pediatric Society · 2020Guideline
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- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
- Distribution of Helicobacter pylori in the Oral Cavity of Patients With Tooth Extractions at Various Locations and Ages.International dental journal · 2026Article
- Prevalence of enteric pathogens in mothers and children from communities in the La Paz River Basin Bolivia; associations with water, sanitation, and hygiene conditions.Journal of water and health · 2026Article
- Rate ofFuture science OA · 2025Article
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- Disparities in overall and site-specific cancer mortality among immigrant generations in Sweden: a nationwide follow-up study over 3 decades.American journal of epidemiology · 2025Article
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- Racial/ethnic differences in risk factors for non-cardia gastric cancer: an analysis of the Multiethnic Cohort (MEC) Study.Cancer causes & control : CCC · 2025Article
- Endoscopic and Histological Gastritis in University Students with Helicobacter pylori Infection.Internal medicine (Tokyo, Japan) · 2024Article
- Lifetime incidence risk for gastric cancer in the Helicobacter pylori-infected and uninfected population in Japan: A Monte Carlo simulation study.International journal of cancer · 2022Article
- DNA vaccine containingIranian journal of basic medical sciences · 2021Article
- Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study.Scientific reports · 2021Article
- Current Prevalence of OralPathogens (Basel, Switzerland) · 2020Article
- Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins.Gastroenterology research and practice · 2020Article
- Atrophic gastritis and chronic diarrhea due to Helicobacter pylori infection in early infancy: A case report.Medicine · 2019Article
- Impact of health insurance coverage forBMJ open · 2017Observational
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have speculated on the possible role of the mother in transmitting Helicobacter pylori infection to their children. In an attempt to either prove or disprove this supposition, we investigated the rates of infection of children born to H. pylori-positive mothers from birth to 5 years of age using serology and the stool antigen test. When infection of the children did occur, the strains from the children were compared to those of their mothers using DNA analysis. Sixty-nine of the 350 pregnant mothers (19.7%) had a positive serology for H. pylori. Fifty-one children underwent serological examinations and stool antigen tests at 4 to 6 days after birth, followed by 1, 3, and 6 months. They were continuously given the stool antigen test at 4- to 6-month intervals until the age of 5 years. Gastric juice samples were collected from the infected children and their mothers for culture and DNA analyses using a random amplified polymorphic DNA fingerprinting method. None of the 51 children acquired H. pylori infection during the first year of life. Of the 44 children enrolled in a 5-year follow-up study, five (11%) acquired H. pylori infection. They acquired the infection at the age of 1 year 2 months, 1 year 3 months, 1 year 6 months, 1 year 8 months, and 4 years 4 months. Random amplified polymorphic DNA fingerprinting confirmed that the strains of the five children exhibited DNA fingerprinting patterns identical to those of their mothers. These findings suggest that mother-to-child transmission is the most probable cause of intrafamilial spread of H. pylori.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.