ArticleJournal of clinical microbiology2005
Genotypic analysis of the earliest known prehistoric case of tuberculosis in Britain.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history.Communications biology · 2023Article
- Article
- TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages.Nature communications · 2020Article
- Tuberculosis in post-contact Native Americans of Brazil: Paleopathological and paleogenetic evidence from the Tenetehara-Guajajara.PloS one · 2018Article
- Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK.PLoS neglected tropical diseases · 2017Article
- Molecular studies on ancient M. tuberculosis and M. leprae: methods of pathogen and host DNA analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
- Co-evolution of Mycobacterium tuberculosis and Homo sapiens.Immunological reviews · 2015Review
- Genotyping of ancient Mycobacterium tuberculosis strains reveals historic genetic diversity.Proceedings. Biological sciences · 2014Article
- Genotype of a historic strain of Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- PCR diagnostics of Mycobacterium tuberculosis in historic human long bone remains from 18th century burials in Kaiserebersdorf, Austria.BMC research notes · 2008Article
- Differential susceptibility of PCR reactions to inhibitors: an important and unrecognised phenomenon.BMC research notes · 2008Article
- Article
- Evaluating bacterial pathogen DNA preservation in museum osteological collections.Proceedings. Biological sciences · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The earliest known case of human tuberculosis in Britain dates to the middle period of the Iron Age, approximately 2,200 years before present. Bone lesions on the spine of a male skeleton excavated at Tarrant Hinton in Dorset, United Kingdom, show evidence of Pott's disease and are supported by molecular evidence of Mycobacterium tuberculosis complex DNA amplified by IS6110 PCR (19). In the present study, we used a further series of sensitive PCR methods to confirm the diagnosis of tuberculosis and to determine the genotype of the infecting strain. These tests demonstrated that this individual was infected with a strain of M. tuberculosis rather than Mycobacterium bovis. The strain had undergone the tuberculosis D1 deletion affecting the mmpS6 and mmpL6 genes and can therefore be identified as a member of the family of "modern" M. tuberculosis isolates. All evidence obtained was consistent with surviving mycobacterial DNA being highly fragmented in this case.
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Registered trials
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