ArticleJournal of clinical microbiology2005
Workload due to Aspergillus fumigatus and significance of the organism in the microbiology laboratory of a general hospital.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- Fungal lung disease.The European respiratory journal · 2024Review
- InvasiveDiagnostics (Basel, Switzerland) · 2022Review
- Clinical features and prognostic analysis of patients with Aspergillus isolation during acute exacerbation of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2021Article
- Epidemiology of invasive pulmonary aspergillosis in patients with liver failure: Clinical presentation, risk factors, and outcomes.The Journal of international medical research · 2018Article
- How much European prescribing physicians know about invasive fungal infections management?BMC infectious diseases · 2015Article
- Microsatellite (STRAf) genotyping cannot differentiate between invasive and colonizing Aspergillus fumigatus isolates.Journal of clinical microbiology · 2015Article
- Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes.Critical care (London, England) · 2015Observational
- Current challenges in the microbiological diagnosis of invasive aspergillosis.Mycopathologia · 2014Review
- Importance of Aspergillus spp. isolation in Acute exacerbations of severe COPD: prevalence, factors and follow-up: the FUNGI-COPD study.Respiratory research · 2014Article
- Clinical and economic burden of invasive fungal diseases in Europe: focus on pre-emptive and empirical treatment of Aspergillus and Candida species.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Assessment of the significance of respiratory culture of Aspergillus in the non-neutropenic patient. A critique of published diagnostic criteria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- Repeated Aspergillus isolation in respiratory samples from non-immunocompromised patients not selected based on clinical diagnoses: colonisation or infection?BMC infectious diseases · 2012Article
- Two cases of aspergillus endocarditis in non neutropenic children on chemotherapy for acute lymphoblastic leukaemia.Hematology reports · 2011Article
- Management of invasive aspergillosis in patients with COPD: rational use of voriconazole.International journal of chronic obstructive pulmonary disease · 2009Review
- Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients.Critical care (London, England) · 2006Article
- A validated clinical approach for the management of aspergillosis in critically ill patients: ready, steady, go!Critical care (London, England) · 2006Review
- Molecular Detection ofInternational journal of applied & basic medical researchArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increase in the immunocompromised population and the incidence of invasive aspergillosis (IA) are leading to an overinterpretation of the potential clinical significance of many isolates of Aspergillus fumigatus. Our work prospectively assesses the workload of the isolation of A. fumigatus and its clinical significance in the microbiology laboratory of a large teaching hospital. During a 3-year period, all patients from whom A. fumigatus was isolated were prospectively monitored and classified as having IA or "nonsignificant" disease. A point score based on the prediction of five easily obtained laboratory and clinical parameters was applied. We found 404 A. fumigatus isolates in 260 patients (1/1,000 microbiology laboratory samples; 2.1 patients/10,000 admissions). A total of 90 isolates (22.3%) were from patients with IA. Of the 260 patients, 31 (12%) had invasive disease (IA), and the remaining 229 had "nonsignificant" disease. A score based on points for five parameters was applied to our population. It was constructed as follows: "sample obtained by invasive procedures" (1 point), "presence of two or more positive samples from the same patient" (1 point), "leukemia" (2 points), "neutropenia" (5 points), and "corticosteroid treatment" (2 points). Patients with a score of 0 had only a 2.5% probability of IA. Those with a score of 1 or 2 had an increased probability of 10.3%. The probabilities rose to 40% and 70%, respectively, for patients with a score of 3 or 4 or a score of > or = 5. A simple score based on five easily available parameters may be of help to microbiologists and clinicians to predict the risk of IA.
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