ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Control of cellular pattern formation in the vertebrate inner retina by homotypic regulation of cell-fate decisions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina.Cell reports · 2024Article
- Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming.Cold Spring Harbor perspectives in biology · 2022Review
- Modeling binary and graded cone cell fate patterning in the mouse retina.PLoS computational biology · 2020Article
- Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression.Neural development · 2017Article
- Design principles and developmental mechanisms underlying retinal mosaics.Biological reviews of the Cambridge Philosophical Society · 2015Review
- Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas.The Journal of biological chemistry · 2014Article
- Retinal Mosaics: Pattern Formation Driven by Local Interactions between Homotypic Neighbors.Frontiers in neural circuits · 2012Article
- Candidate molecular mechanisms for establishing cell identity in the developing retina.Developmental neurobiology · 2011Review
- Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure.BMC developmental biology · 2011Article
- Development of the retina and optic pathway.Vision research · 2011Review
- Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina.Investigative ophthalmology & visual science · 2009Article
- Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.Nature neuroscience · 2009Article
- Neurogenesis in the fish retina.International review of cytology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate retina is composed of cellular arrays that are nonrandom across two-dimensional space. The determinants of these nonrandom two-dimensional cellular patterns in the inner nuclear layer of the retina were investigated using empirical and computational modeling techniques. In normal and experimental models of goldfish retinal growth, the patterns of tyrosine hydroxylase- and serotonin-positive cells indicated that neither cell death nor lateral migration of differentiated cells were dominant mechanisms of cellular pattern formation. A computational model of cellular pattern formation that used a signaling mechanism arising from differentiated cells that inhibited homotypic cell-fate decisions generated accurate simulations of the empirically observed patterns in normal retina. This model also predicted the principal atypical cellular pattern characteristic, a transient cell-type-specific hyperplasia, which was empirically observed in the growing retina subsequent to selective ablation of differentiated retinal cells, either tyrosine hydroxylase positive or serotonin positive. The results support the hypothesis that inhibitory spatiotemporal regulation of homotypic cell-fate decisions is a dominant mechanistic determinant of nonrandom cellular patterns in the vertebrate retina.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.