ReviewNaunyn-Schmiedeberg's archives of pharmacology2005
The TRPC2 ion channel and pheromone sensing in the accessory olfactory system.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025Review
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- Article
- Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Sex-dependent control of pheromones on social organization within groups of wild house mice.Current biology : CB · 2023Article
- Article
- Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb.Neuroscience letters · 2012Article
- Functional and evolutionary aspects of chemoreceptors.Frontiers in cellular neuroscience · 2012Article
- Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels.Pflugers Archiv : European journal of physiology · 2009Article
- Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Organization and function of TRPC channelosomes.Pflugers Archiv : European journal of physiology · 2007Review
- Transient receptor potential (TRP) channels as drug targets.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- Neurobiology of TRPC2: from gene to behavior.Pflugers Archiv : European journal of physiology · 2005Review
- Structure-function analysis of TRPV channels.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
- TRP channels as new pharmacological targets.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Function and pharmacology of TRPM cation channels.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian vomeronasal organ (VNO) has emerged as an excellent model to investigate the signaling mechanisms, mode of activation, biological function, and molecular evolution of transient receptor potential (TRP) channels in real neurons and real physiological systems. TRPC2, a member of the canonical TRPC subfamily, is highly localized to the dendritic tip of vomeronasal sensory neurons. Targeted deletion of the TRPC2 gene has established that TRPC2 plays a fundamental role in the detection of pheromonal signals by the VNO. TRPC2-deficient mice exhibit striking behavioral defects in the regulation of sexual and social behaviors. A novel Ca(2+)-permeable, diacylglycerol-activated cation channel found at the dendritic tip of vomeronasal neurons is severely defective in TRPC2 mutants, providing the first clear example of native diacylglycerol-gated cation channels in the mammalian nervous system. The TRPC2 gene has become an important marker for the evolution of VNO-dependent pheromone signaling in primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.