Trial reportIntensive care medicine2005
Noninvasive pressure support ventilation vs. continuous positive airway pressure in acute hypercapnic pulmonary edema.
Trial report in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema.The Cochrane database of systematic reviews · 2019Pooled it
- Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Guideline
- Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema--a systematic review and meta-analysis.Critical care (London, England) · 2006Pooled it
- A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis.Critical care (London, England) · 2006Pooled it
- Evaluation and Performance of a Positive Airway Pressure Device (CPAP-AirFlife™): A Randomized Crossover Non-Inferiority Clinical Study in Normal Subjects.Medicina (Kaunas, Lithuania) · 2023Trial
- Non-invasive pressure support ventilation and CPAP in cardiogenic pulmonary edema: a multicenter randomized study in the emergency department.Intensive care medicine · 2011Trial
- Continuous positive airway pressure vs. proportional assist ventilation for noninvasive ventilation in acute cardiogenic pulmonary edema.Intensive care medicine · 2008Trial
- Impact of continuous positive airway pressure on the pulmonary changes promoted by immersion in water.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaTrial
- Effect Modification by Acute Coronary Syndrome Prevalence on Non-Invasive Ventilation Efficacy in Acute Cardiogenic Pulmonary Edema: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of cardiovascular development and disease · 2026Review
- Heart-Lungs interactions: the basics and clinical implications.Annals of intensive care · 2024Review
- Feasibility of Early Noninvasive Ventilation Strategy for Patients with Acute Onset Shortness of Breath in Emergency Department - A Prospective Interventional Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- 2019 Focused Update of the Guidelines of the Taiwan Society of Cardiology for the Diagnosis and Treatment of Heart Failure.Acta Cardiologica Sinica · 2019Review
- Noninvasive ventilation in acute respiratory failure.International journal of chronic obstructive pulmonary disease · 2014Review
- Invasive and non-invasive mechanical ventilation.Medicine (Abingdon, England : UK ed.) · 2012Review
- Negative pressure pulmonary edema with laryngeal mask airway use: Recognition, pathophysiology and treatment modalities.International journal of critical illness and injury science · 2012Article
- Review
- Noninvasive ventilation or continuous positive airway pressure in pulmonary edema patients with respiratory acidosis? Look at the bicarbonates.Intensive care medicine · 2011Article
- Recent advances in the role of non-invasive ventilation in acute respiratory failure.Medical journal, Armed Forces India · 2011Article
- Acidemia does not affect outcomes of patients with acute cardiogenic pulmonary edema treated with continuous positive airway pressure.Critical care (London, England) · 2010Article
- Non-invasive ventilation in acute respiratory failure.Lancet (London, England) · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study compared noninvasive pressure support ventilation (NIPSV) and continuous positive airway pressure (CPAP) in patients with acute hypercapnic pulmonary edema with regard to resolution time. DESIGN AND
settingRandomized prospective study in an emergency department. PATIENTS AND
participantsWe randomly assigned 36 patients with respiratory failure due to acute pulmonary edema and arterial hypercapnia (PaCO(2) >45 mmHg) to NIPSV (n=18) or CPAP through a face mask (n=18). MEASUREMENTS AND
resultsElectrocardiographic and physiological measurements were made over 36 h. There was no difference in resolution time defined as clinical improvement with a respiratory rate of fewer than 30 breaths/min and SpO(2)of 96% or more between CPAP and NIPSV groups. Arterial carbon dioxide tension was significantly decreased after 1 h of ventilation (CPAP, 60.5+/-13.6 to 42.8+/-4.9 mmHg; NIPSV, 65.7+/-13.6 to 44.0+/-5.5 mmHg); respective improvements were seen in pH (CPAP, 7.22+/-0.11 to 7.37+/-0.04; NIPSV, 7.19+/-0.11 to 7.38+/-0.04), SpO(2) (CPAP, 86.9+/-3.7% to 95.1+/-2.6%; NIPSV, 83.7+/-6.6% to 96.0+/-2.9%), and respiratory rate (CPAP, 37.9+/-4.5 to 21.3+/-5.1 breaths/min; NIPSV, 39.8+/-4.4 to 21.2+/-4.6 breaths/min). No significant differences were seen with regards to endotracheal intubation and in-hospital mortality.
conclusionsNIPSV proved as effective as CPAP in the treatment of patients with acute pulmonary edema and hypercapnia but did not improve resolution time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.