Evidence map›Paper›PMID 15870830›Full record

GuidelineBritish journal of cancer2005

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

M O Leach, K M Brindle, J L Evelhoch, J R Griffiths, M R Horsman, A Jackson, G C Jayson, I R Judson, M V Knopp, R J Maxwell and 12 more

Registry-linked trialAbstract readGuideline
In one paragraph

Guideline in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05384535 (Utility of Biparametric MRI), which is not on this map. Cited by 174 papers.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05384535 narecruitingnot on this mapstarted 2022, after this paper: background citation

Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort

TypeinterventionalSponsorNorthwell HealthRan2022 to 2028Enrolled100ConditionsProstate Cancer, Magnetic Resonance Imaging, Population at RiskArmsBi-parametric MRI
3 · Its place in the literature

Who cites it

174 citing papers in PubMed.

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  8. ¹⁸F-FDG PET and biomarkers for tumour angiogenesis in early breast cancer.European journal of nuclear medicine and molecular imaging · 2011
    Trial
  9. Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008
    Trial
  10. Article
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  12. Dopamine D2 Receptor Agonists as Modulators of VEGF-A-Driven Angiogenesis: Mechanisms, Clinical Evidence, and Translational Opportunities.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

M O LeachCancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK. martin.leach@icr.ac.uk
K M Brindle
J L Evelhoch
J R Griffiths
M R Horsman
A Jackson
G C Jayson
I R Judson
M V Knopp
R J Maxwell
D McIntyre
A R Padhani
P Price
R Rathbone
G J Rustin
P S Tofts
G M Tozer
W Vennart
J C Waterton
S R Williams
P Workman
Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that considered the methodology and design of magnetic resonance studies, recommending how this new tool might best be used.

Indexed as

Magnetic Resonance ImagingAngiogenesis InhibitorsAntineoplastic AgentsClinical Trials as TopicEvaluation Studies as TopicNeoplasmsReproducibility of ResultsTerminology as TopicAngiogenesis InhibitorsAntineoplastic Agents

Identifiers

PMID15870830
PMCPMC2362033

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.