ArticleApplied and environmental microbiology2005
Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 87 citations in OpenAlex.
- Intracellular β-glucosidase regulates cellulase expression and development in Aspergillus nidulans.Applied microbiology and biotechnology · 2026Article
- Deciphering the role ofMicrobiology spectrum · 2026Article
- Protein secretion and associated stress in industrially employed filamentous fungi.Applied microbiology and biotechnology · 2024Review
- Thiol reductive stress activates the hypoxia response pathway.The EMBO journal · 2023Article
- Physiological ER stress caused by amylase production induces regulated Ire1-dependent mRNA decay in Aspergillus oryzae.Communications biology · 2023Article
- Plasma-mediated enhancement of enzyme secretion in Aspergillus oryzae.Microbial biotechnology · 2021Article
- Improvement of homologous GH10 xylanase production by deletion of genes with predicted function in the Aspergillus nidulans secretion pathway.Microbial biotechnology · 2020Article
- Redesigning N-glycosylation sites in a GH3 β-xylosidase improves the enzymatic efficiency.Biotechnology for biofuels · 2019Article
- Protein profile in Aspergillus nidulans recombinant strains overproducing heterologous enzymes.Microbial biotechnology · 2018Article
- Ultrastructural features of the early secretory pathway in Trichoderma reesei.Current genetics · 2016Article
- Effect of secretory pathway gene overexpression on secretion of a fluorescent reporter protein inFungal biology and biotechnology · 2016Article
- Article
- Investigation of protein secretion and secretion stress in Ashbya gossypii.BMC genomics · 2014Article
- Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30.World journal of microbiology & biotechnology · 2014Article
- Genome-scale analysis of the high-efficient protein secretion system of Aspergillus oryzae.BMC systems biology · 2014Article
- Identification of interphase functions for the NIMA kinase involving microtubules and the ESCRT pathway.PLoS genetics · 2014Article
- The Aspergillus nidulans peripheral ER: disorganization by ER stress and persistence during mitosis.PloS one · 2013Article
- Article
- HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.PLoS pathogens · 2011Article
- Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger.Applied microbiology and biotechnology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Filamentous fungi have a high capacity for producing large amounts of secreted proteins, a property that has been exploited for commercial production of recombinant proteins. However, the secretory pathway, which is key to the production of extracellular proteins, is rather poorly characterized in filamentous fungi compared to yeast. We report the effects of recombinant protein secretion on gene expression levels in Aspergillus nidulans by directly comparing a bovine chymosin-producing strain with its parental wild-type strain in continuous culture by using expressed sequence tag microarrays. This approach demonstrated more subtle and specific changes in gene expression than those observed when mimicking the effects of protein overproduction by using a secretion blocker. The impact of overexpressing a secreted recombinant protein more closely resembles the unfolded-protein response in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.