Evidence map›Paper›PMID 15870326›Full record

ArticleApplied and environmental microbiology2005

Adaptation of Corynebacterium glutamicum to ammonium limitation: a global analysis using transcriptome and proteome techniques.

Maike Silberbach, Mathias Schäfer, Andrea T Hüser, Jörn Kalinowski, Alfred Pühler, Reinhard Krämer, Andreas Burkovski

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Growth ofApplied and environmental microbiology · 2026
    Article
  2. Review
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  4. Article
  5. Article
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  7. Revisiting the Growth Modulon ofFrontiers in bioengineering and biotechnology · 2020
    Article
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  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maike SilberbachInstitut für Biochemie, Universität zu Köln, Zülpicher Strasse 47, D-50674 Köln, Germany.
Mathias Schäfer
Andrea T Hüser
Jörn Kalinowski
Alfred Pühler
Reinhard Krämer
Andreas Burkovski

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theresponse of Corynebacterium glutamicum to ammonium limitation was studied by transcriptional and proteome profiling of cells grown in a chemostat. Our results show that ammonium-limited growth of C. glutamicum results in a rearrangement of the cellular transport capacity, changes in metabolic pathways for nitrogen assimilation, amino acid biosynthesis, and carbon metabolism, as well as a decreased cell division. Since transcription at different growth rates was studied, it was possible to distinguish specific responses to ammonium limitation and more general, growth rate-dependent alterations in gene expression. The latter include a number of genes encoding ribosomal proteins and genes for F(o)F(1)-ATP synthase subunits.

Indexed as

ProteomeTranscription, GeneticAdaptation, PhysiologicalAmino AcidsBiological TransportCarbonCell WallCorynebacterium glutamicumEnergy MetabolismNitrogenQuaternary Ammonium CompoundsAmino AcidsCarbonNitrogenProteomeQuaternary Ammonium Compounds

Identifiers

PMID15870326
PMCPMC1087573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.