Evidence map›Paper›PMID 15867435›Full record

ArticleGenome research2005

Begin at the beginning: predicting genes with 5' UTRs.

Randall H Brown, Samuel S Gross, Michael R Brent

Abstract read
In one paragraph

Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Randall H BrownLaboratory for Computational Genomics, Washington University, St. Louis, MO 63130, USA.
Samuel S Gross
Michael R Brent

Funding

Predicting Gene Structure: Vertebrate Genome ComparisonR01HG002278 · NHGRI · WASHINGTON UNIVERSITY · PI BRENT, MICHAEL R · 2002 to 2008
$1.9M
Maximum Entropy Probability Models for Gene PredictionF33HG002635 · NHGRI · WASHINGTON UNIVERSITY · PI BROWN, RANDALL H · 2003 to 2004
$113k
NHGRI NIH HHS F33 HG002635NHGRI NIH HHS HG 02278NHGRI NIH HHS HG 02635NHGRI NIH HHS R01 HG002278
6 · The paper itself

Abstract

The retrainable, comparative gene predictor N-SCAN integrates multigenome modeling and 5' untranslated region (5' UTR) modeling. In this article, we evaluate N-SCAN's transcription-start site (TSS) and first exon predictions both computationally and experimentally. The computational results indicate that N-SCAN is more accurate than any of the other tools we tested at predicting the TSS and the complete first exon. It is the only one of these tools that can predict complete gene structures together with 5' UTRs. Experimental evaluation shows that N-SCAN can be used to validate novel UTR introns in human gene predictions that do not overlap any RefSeq gene and even to correct RefSeq mRNAs by adding validated UTR exons that are missing from RefSeq.

Indexed as

Genome, HumanModels, Genetic5' Untranslated RegionsBase SequenceComputational BiologyEvaluation Studies as TopicExonsGenesGenomicsHumansMolecular Sequence DataSequence Analysis, DNATranscription Initiation Site5' Untranslated Regions

Identifiers

PMID15867435
PMCPMC1088303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.