ArticleGenome research2005
Conservation of regulatory sequences and gene expression patterns in the disintegrating Drosophila Hox gene complex.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Diversity, duplication, and genomic organization of homeobox genes in Lepidoptera.Genome research · 2023Article
- Dissecting the evolutionary role of theScience advances · 2021Article
- The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation.Nature communications · 2021Article
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- High-Quality Genome Assemblies Reveal Long Non-coding RNAs Expressed in Ant Brains.Cell reports · 2018Article
- Dissecting the Satellite DNA Landscape in Three CactophilicG3 (Bethesda, Md.) · 2017Article
- The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation.Molecular imaging and radionuclide therapy · 2017Article
- Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex.Genetics · 2017Article
- The achaete-scute complex in Diptera: patterns of noncoding sequence evolution.Journal of evolutionary biology · 2015Article
- Genomics of ecological adaptation in cactophilic Drosophila.Genome biology and evolution · 2014Article
- Ancient expansion of the hox cluster in lepidoptera generated four homeobox genes implicated in extra-embryonic tissue formation.PLoS genetics · 2014Article
- An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement.Genome research · 2012Article
- Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription.Nucleic acids research · 2010Article
- The transposon Galileo generates natural chromosomal inversions in Drosophila by ectopic recombination.PloS one · 2009Article
- Analysis of the Tribolium homeotic complex: insights into mechanisms constraining insect Hox clusters.Development genes and evolution · 2008Article
- Comparative phylogenomic analyses of teleost fish Hox gene clusters: lessons from the cichlid fish Astatotilapia burtoni.BMC genomics · 2007Article
- Comparative genomics of ParaHox clusters of teleost fishes: gene cluster breakup and the retention of gene sets following whole genome duplications.BMC genomics · 2007Article
- Protein polymorphism is negatively correlated with conservation of intronic sequences and complexity of expression patterns in Drosophila melanogaster.Journal of molecular evolution · 2007Article
- Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.PloS one · 2007Article
- Inferring genome-scale rearrangement phylogeny and ancestral gene order: a Drosophila case study.Genome biology · 2007Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has been elusive, and it may well be that a single and universal cause does not exist. The Hox-gene complex (HOM-C) has been rearranged differently in several Drosophila species, producing a striking diversity of Hox gene organizations. We investigated the genomic and functional consequences of the two HOM-C splits present in Drosophila buzzatii. Firstly, we sequenced two regions of the D. buzzatii genome, one containing the genes labial and abdominal A, and another one including proboscipedia, and compared their organization with that of D. melanogaster and D. pseudoobscura in order to map precisely the two splits. Then, a plethora of conserved noncoding sequences, which are putative enhancers, were identified around the three Hox genes closer to the splits. The position and order of these enhancers are conserved, with minor exceptions, between the three Drosophila species. Finally, we analyzed the expression patterns of the same three genes in embryos and imaginal discs of four Drosophila species with different Hox-gene organizations. The results show that their expression patterns are conserved despite the HOM-C splits. We conclude that, in Drosophila, Hox-gene clustering is not an absolute requirement for proper function. Rather, the organization of Hox genes is modular, and their clustering seems the result of phylogenetic inertia more than functional necessity.
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