ArticleGenome research2005
Under the genomic radar: the stealth model of Alu amplification.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Comparative genomics reveals LINE-1 recombination with diverse RNAs.Cell genomics · 2026Article
- Article
- Platy-1 SINEs from Thirteen Diverse Genomes Reveal Callithrichidae Unique Amplification, RecentGenes · 2026Article
- Mapping of long interspersed element-1 (L1) insertions by TIPseq provides information about sub chromosomal genetic variation in human embryos.Journal of assisted reproduction and genetics · 2024Article
- Article
- Multiple and diversified transposon lineages contribute to early and recent bivalve genome evolution.BMC biology · 2023Article
- Framework of theGenes · 2023Article
- Alu RNA induces NLRP3 expression through TLR7 activation in α-1-antitrypsin-deficient macrophages.JCI insight · 2022Article
- Review
- A comprehensive analysis of chimpanzee (Pan Troglodytes)-specific AluYb8 element.Genes & genomics · 2020Article
- Pedigree-based estimation of human mobile element retrotransposition rates.Genome research · 2019Article
- A comprehensive analysis of the Baboon-specific full-length LINE-1 retrotransposons.Genes & genomics · 2019Article
- Amplification Dynamics of Platy-1 Retrotransposons in the Cebidae Platyrrhine Lineage.Genome biology and evolution · 2019Article
- Analysis of lineage-specificMobile DNA · 2018Article
- Recently integratedMobile DNA · 2018Article
- Alu Insertion Polymorphisms as Evidence for Population Structure in Baboons.Genome biology and evolution · 2017Article
- Evolution of Alu Subfamily Structure in the Saimiri Lineage of New World Monkeys.Genome biology and evolution · 2017Article
- Insertion and deletion polymorphisms of the ancientMobile DNA · 2017Article
- Discovery of rare, diagnosticMobile DNA · 2017Article
- Structural Variation ofGenomics & informatics · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Alu elements are the most successful SINEs (Short INterspersed Elements) in primate genomes and have reached more than 1,000,000 copies in the human genome. The amplification of most Alu elements is thought to occur through a limited number of hyperactive "master" genes that produce a high number of copies during long evolutionary periods of time. However, the existence of long-lived, low-activity Alu lineages in the human genome suggests a more complex propagation mechanism. Using both computational and wet-bench approaches, we reconstructed the evolutionary history of the AluYb lineage, one of the most active Alu lineages in the human genome. We show that the major AluYb lineage expansion in humans is a species-specific event, as nonhuman primates possess only a handful of AluYb elements. However, the oldest existing AluYb element resided in an orthologous position in all hominoid primate genomes examined, demonstrating that the AluYb lineage originated 18-25 million years ago. Thus, the history of the AluYb lineage is characterized by approximately 20 million years of retrotranspositional quiescence preceding a major expansion in the human genome within the past few million years. We suggest that the evolutionary success of the Alu family may be driven at least in part by "stealth-driver" elements that maintain low retrotranspositional activity over extended periods of time and occasionally produce short-lived hyperactive copies responsible for the formation and remarkable expansion of Alu elements within the genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.