ArticleThe Journal of cell biology2005
Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- The distinct localization of CDC42 isoforms is responsible for their specific functions during migration.The Journal of cell biology · 2024Article
- Identification of GOLPH3 Partners inCells · 2021Article
- Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway.American journal of physiology. Renal physiology · 2021Article
- Collective Polarization of Cancer Cells at the Monolayer Boundary.Micromachines · 2021Article
- Article
- Multifaceted Rho GTPase Signaling at the Endomembranes.Frontiers in cell and developmental biology · 2019Review
- Polarized Exocytosis.Cold Spring Harbor perspectives in biology · 2017Review
- Cdc42 and Cellular Polarity: Emerging Roles at the Golgi.Trends in cell biology · 2016Review
- Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC.Biochemical and biophysical research communications · 2015Article
- PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity.Molecular biology of the cell · 2015Article
- Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.Current biology : CB · 2014Review
- Article
- Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.Small GTPases · 2014Review
- Actin acting at the Golgi.Histochemistry and cell biology · 2013Review
- Organization of the ER-Golgi interface for membrane traffic control.Nature reviews. Molecular cell biology · 2013Review
- Retrograde traffic from the Golgi to the endoplasmic reticulum.Cold Spring Harbor perspectives in biology · 2013Review
- Roles of rho GTPases in intracellular transport and cellular transformation.International journal of molecular sciences · 2013Review
- Charcot-Marie-Tooth disease and intracellular traffic.Progress in neurobiology · 2012Review
- Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cytoskeletal dynamics at the Golgi apparatus are regulated in part through a binding interaction between the Golgi-vesicle coat protein, coatomer, and the regulatory GTP-binding protein Cdc42 (Wu, W.J., J.W. Erickson, R. Lin, and R.A. Cerione. 2000. Nature. 405:800-804; Fucini, R.V., J.L. Chen, C. Sharma, M.M. Kessels, and M. Stamnes. 2002. Mol. Biol. Cell. 13:621-631). The precise role of this complex has not been determined. We have analyzed the protein composition of Golgi-derived coat protomer I (COPI)-coated vesicles after activating or inhibiting signaling through coatomer-bound Cdc42. We show that Cdc42 has profound effects on the recruitment of dynein to COPI vesicles. Cdc42, when bound to coatomer, inhibits dynein binding to COPI vesicles whereas preventing the coatomer-Cdc42 interaction stimulates dynein binding. Dynein recruitment was found to involve actin dynamics and dynactin. Reclustering of nocodazole-dispersed Golgi stacks and microtubule/dynein-dependent ER-to-Golgi transport are both sensitive to disrupting Cdc42 mediated signaling. By contrast, dynein-independent transport to the Golgi complex is insensitive to mutant Cdc42. We propose a model for how proper temporal regulation of motor-based vesicle translocation could be coupled to the completion of vesicle formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.