ArticleEnvironmental health perspectives2005
Symptomatic effects of exposure to diluted air sampled from a swine confinement atmosphere on healthy human subjects.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Respiratory health effects of exposure to low levels of airborne endotoxin - a systematic review.Environmental health : a global access science source · 2018Pooled it
- Updated systematic review: associations between proximity to animal feeding operations and health of individuals in nearby communities.Systematic reviews · 2017Pooled it
- The association between proximity to animal feeding operations and community health: a systematic review.PloS one · 2010Pooled it
- Microbial Volatile Organic Compounds (MVOCs) - rare cause of occupational asthma in two veterinarians.Respiratory medicine case reports · 2026Article
- Swine production intensity and swine-specific fecal contamination of household surfaces at residences of industrial livestock operation workers and community residents, North Carolina, USA.The Science of the total environment · 2025Article
- Residents' experiences during a hydrogen sulfide crisis in Carson, California.Environmental health : a global access science source · 2024Article
- Residents' experiences during a hydrogen sulfide crisis in Carson, California.Research square · 2023Article
- Low level exposure to hydrogen sulfide: a review of emissions, community exposure, health effects, and exposure guidelines.Critical reviews in toxicology · 2023Review
- Effects of elevated CORespiratory research · 2021Article
- Bioaerosols Play a Major Role in the Nasopharyngeal Microbiota Content in Agricultural Environment.International journal of environmental research and public health · 2019Article
- Spatial Variation of Endotoxin Concentrations Measured in Ambient PMEnvironmental health perspectives · 2018Article
- Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116.PloS one · 2018Article
- Performance of a whole-body human dust inhalation challenge exposure chamber.Toxicology reports · 2018Article
- Hydrogen sulfide concentrations at three middle schools near industrial livestock facilities.Journal of exposure science & environmental epidemiology · 2017Article
- Effect of low-level COJournal of occupational medicine and toxicology (London, England) · 2017Article
- Industrial Food Animal Production and Community Health.Current environmental health reports · 2015Review
- cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Respiratory and sensory irritation symptoms among residents exposed to low-to-moderate air pollution from biodegradable wastes.Journal of exposure science & environmental epidemiology · 2014Article
- Challenges and benefits of conducting environmental justice research in a school setting.New solutions : a journal of environmental and occupational health policy : NS · 2014Article
- Air pollution from industrial swine operations and blood pressure of neighboring residents.Environmental health perspectives · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aerial emissions from a swine house at North Carolina State University's field laboratory were diluted to a level that could occur at varying distances downwind from a confined animal feeding operation (CAFO) both within and beyond the property line, and these emissions were delivered to an environmental exposure chamber. The study design consisted of two 1-hr sessions, one in which 48 healthy human adult volunteers were exposed to diluted swine air and another in which they were exposed to clean air (control). Objective measures of blood pressure, temperature, heart rate, respiratory rate, lung function, nasal inflammation, secretory immunity, mood, attention, and memory were correlated with objective measures of air quality. Ratings of perceived (self-reported) health symptoms were also obtained. The mean levels of airborne constituents in the swine air condition were hydrogen sulfide (24 ppb), ammonia (817 ppb), total suspended particulates (0.0241 mg/m3), endotoxin (7.40 endotoxin units/m3), and odor (57 times above odor threshold). No statistical differences on objective measures of physical symptoms, mood, or attention resulted from the 1-hr exposure to swine emissions in the environmental chamber when compared with clean air for healthy human volunteers. However, subjects were 4.1 (p = 0.001) times more likely to report headaches, 6.1 (p = 0.004) times more likely to report eye irritation, and 7.8 (p = 0.014) times more likely to report nausea in the swine air (experimental) condition than in the control condition. These results indicate that short-term exposure in an environmental chamber to malodorous emissions from a swine house at levels expected downwind can induce clinically important symptoms in healthy human volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.