ArticleEnvironmental health perspectives2005
Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.Mutation research. Reviews in mutation researchPooled it
- Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.PloS one · 2015Trial
- Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients.Radiation and environmental biophysics · 2010Trial
- Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV.Environmental and molecular mutagenesisTrial
- Genomic Instability in the Lymphocytes of Dogs with Squamous Cell Carcinoma.Animals : an open access journal from MDPI · 2024Article
- The presence of circulating genetically abnormal cells in blood predicts risk of lung cancer in individuals with indeterminate pulmonary nodules.BMC pulmonary medicine · 2023Article
- Alleviation of nicotine-induced reproductive disorder, clastogenicity, and histopathological alterations by fenugreek saponin bulk and nanoparticles in male rats.Environmental science and pollution research international · 2022Article
- Chromosome Damage in Relation to Recent Radiation Exposure and Radiation Quality in Nuclear Power Plant Workers.Toxics · 2022Article
- Cytogenetic Consequences of Food Industry Workers Occupationally Exposed to Cooking Oil Fumes (COFs).Asian Pacific journal of cancer prevention : APJCP · 2021Article
- The association of three DNA repair genes polymorphisms on the frequency of chromosomal alterations detected by fluorescence in situ hybridization.International archives of occupational and environmental health · 2021Article
- DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death.Scientific reports · 2021Article
- DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations.Frontiers in genetics · 2021Article
- Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Review
- Genotoxic effects of tobacco use in residents of hilly areas and foot hills of Western Ghats, Southern India.Scientific reports · 2019Article
- Substantial Evidences Indicate That Inorganic Arsenic Is a Genotoxic Carcinogen: a Review.Toxicological research · 2018Review
- Cytogenetic abnormalities of the descendants of permanent residents of heavily contaminated East Kazakhstan.Radiation and environmental biophysics · 2017Article
- Polymorphisms of GSTM1, GSTT1, GSTP1 genes and chromosomal aberrations in lung cancer patients.Journal of cancer research and clinical oncology · 2017Article
- Assessment of genotoxicity amongst smokers, alcoholics, and tobacco chewers of North India using micronucleus assay and urinary 8-hydroxyl-2'-deoxyguanosine, as biomarkers.Environmental monitoring and assessment · 2017Article
- Oncogenomic disruptions in arsenic-induced carcinogenesis.Oncotarget · 2017Review
- Aberrations Involving Chromosome 1 as a Possible Predictor of Odds Ratio for Colon Cancer--Results from the Krakow Case-Control Study.PloS one · 2016Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence that increased frequency of chromosomal aberration (CA) in peripheral blood lymphocytes is a predictor of cancer, but further data are needed to better characterize CA as marker of cancer risk. From the archives of 15 laboratories we gathered cytogenetic records of 11,834 subjects who were free of cancer at the moment of blood drawing and who underwent cytogenetic examination for preventive purposes in the Czech Republic during 1975-2000. We linked these records to the national cancer registry, revealing a total of 485 cancer cases. Subjects were classified according to the percentiles of CA distribution within each laboratory as low (0-33rd percentile), medium (34-66th percentile), and high (66-100th percentile). Subjects were further classified by occupational exposure and by subclass of CA. We found a significant association between the overall cancer incidence and the presence of chromosome-type aberrations [relative risk (RR) for high vs. low CA level = 1.24; 95% confidence interval (CI), 1.03-1.50] but not chromatid-type aberrations. Stomach cancer showed a strong association with frequency of total CA (RR = 7.79; 95% CI, 1.01-60.0). The predictivity of CA observed in subjects exposed to various classes of carcinogens did not significantly differ from the group of nonexposed subjects. This study contributes to validation of CA as a predictive marker of cancer risk, in particular, of stomach cancer; the association between CA frequency and cancer risk might be limited to chromosome-type aberrations.
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