ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2005
May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis.PloS one · 2013Pooled it
- Low expression of GSTP1 in the aqueous humour of patients with primary open-angle glaucoma.Journal of cellular and molecular medicine · 2021Article
- Glutathione S-Transferase Omega-2 and Transforming Growth Factor-Journal of ophthalmology · 2021Article
- Article
- Involvement of Nrf2 in Ocular Diseases.Oxidative medicine and cellular longevity · 2017Review
- Glaucoma related Proteomic Alterations in Human Retina Samples.Scientific reports · 2016Article
- Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma.Iranian journal of basic medical sciences · 2014Article
- Determination of morphological, biometric and biochemical susceptibilities in healthy Eurasier dogs with suspected inherited glaucoma.PloS one · 2014Article
- The Role of Oxidative Stress and Vascular Insufficiency in Primary Open Angle Glaucoma.Clujul medical (1957) · 2014Review
- Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?Molecular vision · 2011Article
- Article
- Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients.Molecular vision · 2008Article
- Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population.The British journal of ophthalmology · 2007Article
- Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG).Molecular vision · 2007Article
- Polymorphism of CYP46A1 and PPARγ2 Genes in Risk Prediction of Primary Open Angle Glaucoma Among North Indian Population.Middle East African journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.
methodsWe genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.
resultsThe frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.
conclusionThe present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.
Indexed as
Identifiers
15864623What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.