ArticleSurgery today2005
A clinicopathological investigation of "tumor nodules" in colorectal cancer.
Article in Surgery today, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- The Prognostic Impact of Imaging Detected Tumor Deposits in Rectal Cancer: A Systematic Review and Meta-analysis.Annals of surgical oncology · 2026Pooled it
- Tumour deposits are associated with worse survival than extranodal extension; a network meta-analysis on tumour nodules in colorectal cancer.Histopathology · 2025Pooled it
- Prognostic value of tumor deposits for long-term oncologic outcomes in patients with stage III colorectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Independent prognostic value of tumor deposits in stage III colorectal cancer: a large-scale systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer.World journal of gastrointestinal oncology · 2023Article
- Risk factors predict microscopic extranodal tumor deposits in advanced stage III colon cancer patients.World journal of gastroenterology · 2023Article
- Significance of tumor deposits combined with lymph node metastasis in stage III colorectal cancer patients: a retrospective multi-center cohort study from China.International journal of colorectal disease · 2022Article
- Magnetic Compression of Tumor Spheroids Increases Cell Proliferation In Vitro and Cancer Progression In Vivo.Cancers · 2022Article
- Association of KRAS mutation with tumor deposit status and overall survival of colorectal cancer.Cancer causes & control : CCC · 2020Article
- The Role of Tumor Deposits in Predicting the Efficacy of Chemotherapy in Stage III Colon Cancer.Frontiers in oncology · 2020Article
- The unique prognostic characteristics of tumor deposits in colorectal cancer patients.Annals of translational medicine · 2019Article
- Prognostic significance and role in TNM stage of tumor deposits in esophageal cancer.Journal of thoracic disease · 2017Article
- Prognostic significance of perigastric tumor deposits in patients with primary gastric cancer.BMC surgery · 2017Article
- Article
- Tumor deposits counted as positive lymph nodes in TNM staging for advanced colorectal cancer: a retrospective multicenter study.Oncotarget · 2016Article
- Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors?Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Effect of tumor deposits on overall survival in colorectal cancer patients with regional lymph node metastases.Journal of rural medicine : JRM · 2014Article
- Analysis of the seventh edition of American Joint Committee on colon cancer staging.International journal of colorectal disease · 2012Article
- Can the tumor deposits be counted as metastatic lymph nodes in the UICC TNM staging system for colorectal cancer?PloS one · 2012Article
- Lymph node negative colorectal cancers with isolated tumor deposits should be classified and treated as stage III.Annals of surgical oncology · 2010Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTumor nodules (tn) have been histologically identified within the fatty tissue or the detached fatty tissue around dissected lymph nodes, or else picked up as lymph nodes from resected specimens with no lymph node components. The TNM classification of malignant tumors provides a description of how to deal with tn, but there has so far been no description within the Japanese classification of colorectal carcinoma. The aim of this study was to determine whether we should regard tn as metastatic lymph nodes from the viewpoint of prognosis.
methodsA total of 544 patients who underwent a resection of colorectal adenocarcinoma between 1985 and 1995 were reviewed.
resultsTumor nodules were found in 54 (17.6%) of 307 colon cancer patients, and in 41 (17.3%) of 237 rectal cancer patients. We classified the curability A patients into four groups for both colon and rectal cancer; positive lymph nodes with tn (Group A), negative lymph nodes with tn (Group B), positive lymph nodes without tn (Group C), and negative lymph nodes without tn (Group D). The prognosis was not significantly different between Groups A, B, and C, but it was significantly different between Group D and Groups A, B, and C (P < 0.01) in both the colon and the rectum.
conclusionFrom the viewpoint of prognosis, it thus appears justifiable to regard tn as lymph node metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.