Evidence map›Paper›PMID 15864412›Full record

ArticleJournal of human genetics2005

Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene (POMC) with low bone mineral density in adult women.

Yoshihiro Sudo, Yoichi Ezura, Mitsuko Kajita, Hideyo Yoshida, Takao Suzuki, Takayuki Hosoi, Satoshi Inoue, Masataka Shiraki, Hiromoto Ito, Mitsuru Emi

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Crosstalk of Brain and Bone-Clinical Observations and Their Molecular Bases.International journal of molecular sciences · 2020
    Review
  2. Genetic aspects of osteoporosis.Journal of bone and mineral metabolism · 2010
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yoshihiro SudoDepartment of Molecular Biology, Institute of Gerontology, Nippon Medical School Kawasaki, Kanagawa, Japan.
Yoichi EzuraDepartment of Molecular Biology, Institute of Gerontology, Nippon Medical School Kawasaki, Kanagawa, Japan. ezura.mph@mri.tmd.ac.jp.
Mitsuko KajitaDepartment of Molecular Biology, Institute of Gerontology, Nippon Medical School Kawasaki, Kanagawa, Japan.
Hideyo YoshidaEpidemiology and Health Promotion Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Takao SuzukiEpidemiology and Health Promotion Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Takayuki HosoiDepartment of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
Satoshi InoueDepartment of Geriatric Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Masataka ShirakiResearch Institute and Practice for Involutional Diseases, Nagano, Japan.
Hiromoto ItoDepartment of Orthopaedics, Nippon Medical School, Tokyo, Japan.
Mitsuru EmiDepartment of Molecular Biology, Institute of Gerontology, Nippon Medical School Kawasaki, Kanagawa, Japan.
Nippon Medical School · JPTokyo Metropolitan Institute of Gerontology · JPThe University of Tokyo · JPTokyo Metropolitan Geriatric Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among multiple factors influencing osteoporosis, genetic variations involved in bone-mineral metabolism can affect risks predisposing to the disease onset. Here, we studied single-nucleotide polymorphisms (SNPs) in the pro-opiomelanocortin (POMC) gene for possible association with bone mineral density (BMD) among 384 adult Japanese women and observed significant correlation between adjusted BMD and three SNPs in the promoter region (r>0.14, p<0.01). The most significant correlation was observed for -2353G/A (r=-0.16, p=0.002); homozygous carriers of the major (G) allele had the highest BMD (0.405+/-0.054 g/cm2) while heterozygous carriers were intermediate (0.390+/-0.053 g/cm2) and homozygous A-allele carriers had the lowest BMDs (0.369+/-0.048 g/cm2). Although no association was detected between these SNPs and body weight or body mass index (BMI), significant association was detected between the -2313A/C genotype and plasma total cholesterol level (r=-0.12, p=0.019). We propose that POMC is among the likely susceptibility genes for osteoporosis and may also be involved in dyslipidemia.

Indexed as

AdultAgedBody Mass IndexBody WeightBone DensityCholesterolDisease SusceptibilityFemaleGenotypeHumansMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticPro-OpiomelanocortinRisk FactorsCholesterolPro-Opiomelanocortin

Identifiers

PMID15864412
OpenAlexW2035088711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.