ArticleNature neuroscience2005
Endocannabinoid signaling depends on the spatial pattern of synapse activation.
Article in Nature neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 112 citations in OpenAlex.
- Effect of cannabinoids on glutamate levels in the human brain: a systematic review and meta-analysis.Journal of cannabis research · 2025Review
- Article
- Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression.Journal of neuroinflammation · 2024Article
- Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum.Communications biology · 2024Article
- Article
- Developmental timing-dependent organization of synaptic connections between mossy fibers and granule cells in the cerebellum.Communications biology · 2023Article
- Reply to Piochon et al.: NMDARs in Purkinje cells are not involved in parallel fiber-Purkinje cell synaptic plasticity or motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The relationship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Potential and Realized Impact of Astroglia CaFrontiers in cellular neuroscience · 2021Review
- Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis.Cerebellum (London, England) · 2020Review
- Activation of the mGluMolecular psychiatry · 2020Article
- Long-term depression of presynaptic cannabinoid receptor function at parallel fibre synapses.The Journal of physiology · 2019Article
- Two Distinct Sets of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity.eLife · 2017Article
- Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase.Scientific reports · 2016Article
- Emerging Trends in Retrograde Signaling.Molecular neurobiology · 2016Review
- Role of astrocytic glutamate transporter in alcohol use disorder.World journal of psychiatry · 2016Review
- The ubiquitous nature of multivesicular release.Trends in neurosciences · 2015Review
- Cerebellar endocannabinoids: retrograde signaling from purkinje cells.Cerebellum (London, England) · 2015Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The brain's endocannabinoid retrograde messenger system decreases presynaptic transmitter release, but its physiological function is uncertain. We show that endocannabinoid signaling is absent when spatially dispersed synapses are activated on rodent cerebellar Purkinje cells but that it reduces presynaptic glutamate release when nearby synapses are active. This switching of signaling according to the spatial pattern of activity is controlled by postsynaptic type I metabotropic glutamate receptors, which are activated disproportionately when glutamate spillover between synapses produces synaptic crosstalk. When spatially distributed synapses are activated, endocannabinoid inhibition of transmitter release can be rescued by inhibiting glutamate uptake to increase glutamate spillover. Endocannabinoid signaling initiated by type I metabotropic glutamate receptors is a homeostatic mechanism that detects synaptic crosstalk and downregulates glutamate release in order to promote synaptic independence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.