ArticleJournal of medical genetics2005
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Article in Journal of medical genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00289237 (A Randomised Non-pharmacological Intervention Study for Prevention of Ischaemic Heart Disease Inter99), which is not on this map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Non-pharmacological Intervention Study for Prevention of Ischaemic Heart Disease Inter99
Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants.Drug development research · 2020Article
- PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells.Cancer cell international · 2019Article
- Levamisole suppresses adipogenesis of aplastic anaemia-derived bone marrow mesenchymal stem cells through ZFP36L1-PPARGC1B axis.Journal of cellular and molecular medicine · 2018Article
- PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level.Oncotarget · 2017Article
- Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity.BMC genomics · 2017Article
- Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.CNS neuroscience & therapeutics · 2017Review
- PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids.Molecular metabolism · 2015Article
- Genetic variants associated with sleep disorders.Sleep medicine · 2015Article
- Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology.Seminars in immunopathology · 2014Review
- Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.Annals of human genetics · 2014Article
- Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.Human molecular genetics · 2013Article
- Redox regulation of mitochondrial biogenesis.Free radical biology & medicine · 2012Review
- Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.Biochimica et biophysica acta · 2012Review
- Mitochondrial dysfunction in obesity.Current opinion in endocrinology, diabetes, and obesity · 2010Review
- Recent progress in the genetics of common obesity.British journal of clinical pharmacology · 2009Review
- Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Article
- A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.American journal of human genetics · 2007Article
- Diesel exhaust particle-induced airway responses are augmented in obese rats.International journal of toxicologyArticle
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.
methodsWe studied variation in the coding region of human PPARGC1B in Danish whites and related these variations to the prevalence of obesity and type 2 diabetes in population based samples.
resultsTwenty nucleotide variants were identified. In a study of 525 glucose tolerant subjects, the Ala203Pro and Val279Ile variants were in almost complete linkage disequilibrium (R2 = 0.958). In a case-control study of obesity involving a total of 7790 subjects, the 203Pro allele was significantly less frequent among obese participants (p = 0.004; minor allele frequencies: normal weight subjects 8.1% (95% confidence interval: 7.5 to 8.8), overweight subjects 7.6% (7.0 to 8.3), obese subjects 6.5% (5.6 to 7.3)). In a case-control study involving 1433 patients with type 2 diabetes and 4935 glucose tolerant control subjects, none of the examined variants were associated with type 2 diabetes.
conclusionsVariation of PGC-1beta may contribute to the pathogenesis of obesity, with a widespread Ala203 allele being a risk factor for the development of this common disorder.
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