Trial reportArchives of disease in childhood. Fetal and neonatal edition2005
Does the use of 50% oxygen at birth in preterm infants reduce lung injury?
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth.The Cochrane database of systematic reviews · 2018Pooled it
- Lower versus higher oxygen concentration for delivery room stabilisation of preterm neonates: systematic review.PloS one · 2012Pooled it
- Trial
- Trial
- Periviable antenatal care, labor and delivery, and initial resuscitation: Some chores to get done before you start.Pediatric research · 2026Review
- Article
- The Respiratory Management of the Extreme Preterm in the Delivery Room.Children (Basel, Switzerland) · 2023Review
- Optimizing oxygen therapy for preterm infants at birth: Are we there yet?Seminars in fetal & neonatal medicine · 2020Review
- Oxygen therapy of the newborn from molecular understanding to clinical practice.Pediatric research · 2019Review
- Is There a "Right" Amount of Oxygen for Preterm Infant Stabilization at Birth?Frontiers in pediatrics · 2019Review
- Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2018Article
- Delivery room interventions to prevent bronchopulmonary dysplasia in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2017Review
- Resuscitation of extremely preterm infants - controversies and current evidence.World journal of clinical pediatrics · 2016Review
- Delivery room resuscitation of preterm infants in Canada: current practice and views of neonatologists at level III centers.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
- Neonatal resuscitation for the preterm infant: evidence versus practice.Journal of perinatology : official journal of the California Perinatal Association · 2010Review
- Inflammatory response in preterm infants is induced early in life by oxygen and modulated by total parenteral nutrition.Pediatric research · 2010Article
- Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions.BMC pregnancy and childbirth · 2010Review
- Pinching, electrocution, ravens' beaks, and positive pressure ventilation: a brief history of neonatal resuscitation.Archives of disease in childhood. Fetal and neonatal edition · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchopulmonary dysplasia is an inflammatory fibrotic condition produced as a consequence of injurious influences in the neonatal lung. Exposing the premature lung to high concentrations of oxygen is thought to play an important part in lung injury pathogenesis.
objectiveTo see if the amount of oxygen used during resuscitation at birth triggers events that lead to the subsequent lung injury and if a reduction in oxygen used leads to a reduction in lung injury.
methodThe outcomes of newborn babies less than 31 weeks gestation who were resuscitated using either 50% or 100% oxygen were examined. Eight of the babies receiving 50% oxygen required an increase in their oxygen concentration. Evidence of pulmonary inflammation was determined by quantifying interleukin 6, 1beta, and 10 and tumour necrosis factor alpha in bronchoalveolar lavage fluid by enzyme linked immunosorbent assay.
resultsThere were no significant differences in any of the cytokines studied in either of the groups. Death occurred in 5/26 (19%) babies who received 100% oxygen and 4/26 (15%) babies who received 50% oxygen. Survival without bronchopulmonary dysplasia at 36 weeks postmenstrual age occurred in 14/26 (54%) and 13/26 (50%).
conclusionReducing the oxygen to 50% at resuscitation did not influence either short or long term outcomes, but a small benefit could not be excluded. There was no increase in adverse clinical outcomes in babies who received 100% oxygen.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.