ArticleBiophysical journal2005
Lateral diffusion coefficients of separate lipid species in a ternary raft-forming bilayer: a Pfg-NMR multinuclear study.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 94 citations in OpenAlex.
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- Spontaneous Membrane Nanodomain Formation in the Absence or Presence of the Neurotransmitter Serotonin.Frontiers in cell and developmental biology · 2020Article
- Surface Shear Viscosity and Interleaflet Friction from Nonequilibrium Simulations of Lipid Bilayers.Journal of chemical theory and computation · 2019Article
- Accelerating Membrane Simulations with Hydrogen Mass Repartitioning.Journal of chemical theory and computation · 2019Article
- Role of Inverse-Cone-Shape Lipids in Temperature-Controlled Self-Reproduction of Binary Vesicles.Biophysical journal · 2016Article
- Atomistic Monte Carlo simulation of lipid membranes.International journal of molecular sciences · 2014Review
- The molecular structure of the liquid-ordered phase of lipid bilayers.Journal of the American Chemical Society · 2014Article
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- Drag coefficient of a liquid domain in a two-dimensional membrane.The European physical journal. E, Soft matter · 2010Article
- Segregated phases in pulmonary surfactant membranes do not show coexistence of lipid populations with differentiated dynamic properties.Biophysical journal · 2009Article
- Reversible formation of nanodomains in monolayers of DPPC studied by kinetic modeling.Biophysical journal · 2009Article
- Unrestricted diffusion of exogenous and endogenous PIP(2 )in baby hamster kidney and Chinese hamster ovary cell plasmalemma.The Journal of membrane biology · 2007Article
- Domain formation in model membranes studied by pulsed-field gradient-NMR: the role of lipid polyunsaturation.Biophysical journal · 2007Article
- Plasma membrane sterol distribution resembles the surface topography of living cells.Molecular biology of the cell · 2007Article
- Domain-formation in DOPC/SM bilayers studied by pfg-NMR: effect of sterol structure.Biophysical journal · 2006Article
- Sphingomyelin structure influences the lateral diffusion and raft formation in lipid bilayers.Biophysical journal · 2006Article
- Theory of the deuterium NMR of sterol-phospholipid membranes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By isotopical labeling lipid lateral diffusion coefficients for each of the membrane constituents, including cholesterol, have been measured by 1H, 2H, and 19F pulsed field gradient NMR spectroscopy in macroscopically oriented lipid bilayers. This provides a means of obtaining detailed dynamic and compositional information in raft-forming lipid bilayers without introducing foreign molecules into the systems. The raft systems studied contained dioleoylphosphatidylcholine/dipalmitoylphosphatidylcholine (DPPC)/cholesterol at the molar ratios of 42.5:42.5:15 and 35:35:30 in excess water. At temperatures below 30 degrees C the raft system forms large (>1 microm) domains of a liquid ordered (l(o)) phase, in which the lipid lateral diffusion was approximately 5 times slower than for the lipids in the surrounding liquid disordered (l(d)) phase. Within each domain all lipid species showed the same diffusion coefficient, despite the very different structures of cholesterol and phospholipids. DPPC partitions exclusively into the l(o) domains, whereas cholesterol and dioleoylphosphatidylcholine were distributed in both l(o) and l(d) phases. The cholesterol concentration was found to be 10-20 mol % in the l(d) domain and 30-40 mol % in the l(o) domain. Comparison of these results with data from sphingomyelin-containing systems suggests that DPPC interacts more weakly with cholesterol than does sphingomyelin.
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