Evidence map›Paper›PMID 15863468›Full record

Trial reportArchives of disease in childhood2005

Effects of probiotics on atopic dermatitis: a randomised controlled trial.

S Weston, A Halbert, P Richmond, S L Prescott

4 registry-linked trialsAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 89 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00294788 phase1 / phase2unknown statusnot on this mapstarted 2006, after this paper: background citation

Phase I/II Placebo-Controlled Study of Consumption of a Probiotic on HAI Titre Following Influenza Vaccination of Healthy Adult Subjects

TypeinterventionalSponsorProbiomics LtdRan2006 to 2007Enrolled300ConditionsInfluenzaArmsFluvax, PCC® (Lactobacillus fermentum VRI 003)
NCT00378300 nawithdrawnnot on this mapstarted 2007, after this paper: background citation

Probiotics Ameliorate Atopic Dermatitis by Induction of T Regulatory Cells

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2008Enrolled0ConditionsAtopic DermatitisArmsOral Probiotics
NCT03042624 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Efficacy of Fermented Rice Flour for the Treatment of Atopic Dermatitis: Randomized, Double-blind Controlled Trial

TypeinterventionalSponsorUniversity of MilanRan2017 to 2017Enrolled50ConditionsDermatitis, Atopic, Child, InfantArmsFermented rice, Maltodextrins
NCT03157284 nacompletednot on this mapstarted 2017, after this paper: background citation

Efficacy of Fermented Rice Flour for the Treatment of Atopic Dermatitis : Randomized, Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorHeinz Italia SpARan2017 to 2019Enrolled58ConditionsAtopic DermatitisArmsRice Flour, Placebo
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Probiotics in infants for prevention of allergic disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Probiotics for treating eczema.The Cochrane database of systematic reviews · 2018
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Eczema.BMJ clinical evidence · 2011
    Pooled it
  8. Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Trial
  9. Trial
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  14. Review
  15. Article
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  20. Daily Supplementation withFoods (Basel, Switzerland) · 2024
    Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

S WestonSchool of Paediatrics and Child Health Research, University of Western Australia, Perth, Australia. susanp@ichr.uwa.edu.au
A Halbert
P Richmond
S L Prescott

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the study was to investigate the effects of probiotics on moderate or severe atopic dermatitis (AD) in young children.

methodsFifty six children aged 6-18 months with moderate or severe AD were recruited into a randomised double blind placebo controlled trial in Perth, Western Australia; 53 children completed the study. The children were given a probiotic (1x10(9)Lactobacillus fermentum VRI-033 PCC; Probiomics) or an equivalent volume of placebo, twice daily for 8 weeks. A final assessment at 16 weeks was performed.

resultsThe main outcome measures were severity and extent of AD at the end of the study, as measured by the Severity Scoring of Atopic Dermatitis (SCORAD) index. The reduction in the SCORAD index over time was significant in the probiotic group (p = 0.03) but not the placebo group. Significantly more children receiving probiotics (n = 24, 92%) had a SCORAD index that was better than baseline at week 16 compared with the placebo group (n = 17, 63%) (p = 0.01). At the completion of the study more children in the probiotic group had mild AD (n = 14, 54%) compared to the placebo group (n = 8, 30%).

conclusionSupplementation with probiotic L fermentum VRI-003 PCC is beneficial in improving the extent and severity of AD in young children with moderate or severe disease.

Indexed as

Anti-Allergic AgentsChild, PreschoolDermatitis, AtopicDouble-Blind MethodFemaleFollow-Up StudiesHumansLactobacillusMaleProbioticsSeverity of Illness IndexTreatment OutcomeAnti-Allergic Agents

Identifiers

PMID15863468
PMCPMC1720555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.