ReviewGenomics, proteomics & bioinformatics2004
Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs.
Review in Genomics, proteomics & bioinformatics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- TheMicroorganisms · 2020Review
- Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates fromAntioxidants (Basel, Switzerland) · 2019Article
- Natural radioprotectors and their impact on cancer drug discovery.Radiation oncology journal · 2018Article
- Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds.Journal of clinical and diagnostic research : JCDR · 2017Article
- Identification of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists using molecular modeling method.Journal of computer-aided molecular design · 2014Article
- Computational drug discovery.Acta pharmacologica Sinica · 2012Review
- A comparative reverse docking strategy to identify potential antineoplastic targets of tea functional components and binding mode.International journal of molecular sciences · 2011Article
- Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.Antimicrobial agents and chemotherapy · 2010Article
- PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach.Nucleic acids research · 2010Article
- Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames).BMC structural biology · 2009Article
- Identification of Bacillus anthracis spore component antigens conserved across diverse Bacillus cereus sensu lato strains.Molecular & cellular proteomics : MCP · 2009Article
- Structures of an alanine racemase from Bacillus anthracis (BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P).Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
- A novel immunogenic spore coat-associated protein in Bacillus anthracis: characterization via proteomics approaches and a vector-based vaccine system.Protein expression and purification · 2008Article
- Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Protein science : a publication of the Protein Society · 2006Article
- TarFisDock: a web server for identifying drug targets with docking approach.Nucleic acids research · 2006Article
- New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery.Drug discovery today. Technologies · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this review, we advance a new concept in developing vaccines and/or drugs to target specific proteins expressed during the early stage of Bacillus anthracis (anthrax) infection and address existing challenges to this concept. Three proteins (immune inhibitor A, GPR-like spore protease, and alanine racemase) initially identified by proteomics in our laboratory were found to have differential expressions during anthrax spore germination and early outgrowth. Other studies of different bacillus strains indicate that these three proteins are involved in either germination or cytotoxicity of spores, suggesting that they may serve as potential targets for the design of anti-anthrax vaccines and drugs.
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Registered trials
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