ArticleThe EMBO journal2005
Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies.Cell reports · 2020Article
- Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.Scientific reports · 2016Article
- Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation.Journal of cell science · 2014Article
- Early cardiac development: a view from stem cells to embryos.Cardiovascular research · 2012Review
- Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Cardiac-specific deletion of the microtubule-binding protein CENP-F causes dilated cardiomyopathy.Disease models & mechanisms · 2012Article
- RB1, development, and cancer.Current topics in developmental biology · 2011Review
- Arabidopsis RETINOBLASTOMA-RELATED is required for stem cell maintenance, cell differentiation, and lateral organ production.The Plant cell · 2010Article
- Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.Journal of cell science · 2010Article
- Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.Developmental cell · 2009Article
- Cardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis.Journal of molecular and cellular cardiology · 2008Review
- CMF1-Rb interaction promotes myogenesis in avian skeletal myoblasts.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Enhanced proliferation of monolayer cultures of embryonic stem (ES) cell-derived cardiomyocytes following acute loss of retinoblastoma.PloS one · 2008Article
- Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice.Proteome science · 2007Article
- Cardiac myocyte cell cycle control in development, disease, and regeneration.Physiological reviews · 2007Review
- Review
- Review
- CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25.Molecular biology of the cell · 2006Article
- Embryonic stem cells and cardiomyocyte differentiation: phenotypic and molecular analyses.Journal of cellular and molecular medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms governing early cardiogenesis are still largely unknown. Interestingly, the retinoblastoma protein (Rb), a regulator of cell cycle, has recently emerged as a new candidate regulating cell differentiation. Rb-/- mice die at midgestation and mice lacking E2f1/E2f3, downstream components of the Rb-dependent transcriptional pathway, die of heart failure. To gain insight into the function of Rb pathway in early cardiogenesis, we used Rb-/- embryonic stem (ES) cells differentiating into cardiomyocytes. Rb-/- cells displayed a dramatic delay in expression of cardiac-specific transcription factors and in turn in the whole process of cardiac differentiation. The phenotype of Rb-/- ES cell-derived cardiomyocytes was rescued by reintroducing Rb in cardiac progenitors, by stimulating the BMP-dependent cardiogenic pathway or by overexpression of Nkx2.5. ES cells deficient in the recently identified factor LEK1, a murine homolog of the cardiomyogenic factor 1, or specific disruption of Rb-LEK1 interaction into the nucleus of differentiating ES cells recapitulated the delay in cardiac differentiation of Rb-/- ES cells. Thus, we provide evidence for a novel Rb/LEK1-dependent and BMP-independent transcriptional program, which plays a pivotal role in priming ES cells toward a cardiac fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.