Evidence map›Paper›PMID 15860827›Full record

Trial reportBMJ (Clinical research ed.)2005

Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care.

Jill Porthouse, Sarah Cockayne, Christine King, Lucy Saxon, Elizabeth Steele, Terry Aspray, Mike Baverstock, Yvonne Birks, Jo Dumville, Roger Francis and 5 more

Registry-linked trialOpen access · bronzeAbstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02735200 (Topical Delivery of Vitamin D3), which is not on this map. Cited by 145 papers, 38 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 38 pooled it
54.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02735200 phase2completednot on this mapstarted 2016, after this paper: background citation

Topical Delivery of Vitamin D3: A Randomized Controlled Trial (RCT)

TypeinterventionalSponsorImam Abdulrahman Bin Faisal UniversityRan2016 to 2016Enrolled550ConditionsVitamin D DeficiencyArmsApplication of topical vitamin d3 (Top-D), Application of Aloe vera gel
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 38 syntheses or guidelines pooled it, 523 citations in OpenAlex.

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  19. Atencion primaria · 2018
    Guideline
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jill PorthouseYork Trials Unit, Department of Health Sciences, University of York, York YO10 5DD.
Sarah Cockayne
Christine King
Lucy Saxon
Elizabeth Steele
Terry Aspray
Mike Baverstock
Yvonne Birks
Jo Dumville
Roger Francis
Cynthia Iglesias
Suezann Puffer
Anne Sutcliffe
Ian Watt
David J Torgerson
University of York · GBFreeman Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess whether supplementation with calcium and cholecaliferol (vitamin D3) reduces the risk of fracture in women with one or more risk factors for fracture of the hip.

designPragmatic open randomised controlled trial.

settingPractice nurse led clinics in primary care.

participants3314 women aged 70 and over with one or more risk factors for hip fracture: any previous fracture, low body weight (< 58 kg), smoker, family history of hip fracture, or fair or poor self reported health.

interventionDaily oral supplementation using 1000 mg calcium with 800 IU cholecaliferol and information leaflet on dietary calcium intake and prevention of falls, or leaflet only (control group).

main outcome measuresPrimary outcome measure was all clinical fractures and secondary outcome measures were adherence to treatment, falls, and quality of life (measured with the SF-12).

results69% of the women who completed the follow-up questionnaire at 24 months were still taking supplements (55% with inclusion of randomised participants known to be alive). After a median follow-up of 25 months (range 18 to 42 months), clinical fracture rates were lower than expected in both groups but did not significantly differ for all clinical fractures (odds ratio for fracture in supplemented group 1.01, 95% confidence interval 0.71 to 1.43). The odds ratio for hip fracture was 0.75 (0.31 to 1.78). The odds of a woman having a fall at six and 12 months was 0.99 and 0.98, respectively. Quality of life did not significantly differ between the groups.

conclusionWe found no evidence that calcium and vitamin D supplementation reduces the risk of clinical fractures in women with one or more risk factors for hip fracture. Registration ISRCTN26118436, controlled trials registry.

Indexed as

Administration, OralAgedCholecalciferolFemaleHip FracturesHumansPilot ProjectsRisk FactorsTreatment OutcomeVitamin DCholecalciferolVitamin D

Identifiers

PMID15860827
PMCPMC557150
OpenAlexW2122398315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.