Trial reportAmerican journal of respiratory and critical care medicine2005
Failure of high-dose ergocalciferol to correct vitamin D deficiency in adults with cystic fibrosis.
Trial report in American journal of respiratory and critical care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00956839 (Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis
Who cites it
19 citing papers in PubMed.
- Prospective, Randomized, Double-Blind, Parallel-Group, Comparative Effectiveness Clinical Trial Comparing a Powder Vehicle Compound of Vitamin D With an Oil Vehicle Compound in Adults With Cystic Fibrosis.JPEN. Journal of parenteral and enteral nutrition · 2017Trial
- Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light.The Journal of clinical endocrinology and metabolism · 2009Trial
- Bioavailability of a novel, water-soluble vitamin E formulation in malabsorbing patients.Digestive diseases and sciences · 2007Trial
- Cystic fibrosis-related bone disease: an update on screening, diagnosis, and treatment.Therapeutic advances in endocrinology and metabolism · 2025Review
- Abnormal changes of bone metabolism markers with age in children with cerebral palsy.Frontiers in pediatrics · 2023Article
- Molecular Heterogeneity in Cystic Fibrosis.Journal of pediatric genetics · 2020Article
- Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis.International journal of endocrinology · 2018Article
- Treatment of vitamin D deficiency in cystic fibrosis.The Journal of steroid biochemistry and molecular biology · 2016Review
- Relationship Between Fat-Soluble Vitamin Supplementation and Blood Concentrations in Adolescent and Adult Patients With Cystic Fibrosis.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2014Article
- Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation: A randomized, controlled trial.Dermato-endocrinology · 2012Article
- Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis.European journal of clinical nutrition · 2011Article
- Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies.Advances in nutrition (Bethesda, Md.) · 2011Review
- Vitamin d deficiency in cystic fibrosis.International journal of endocrinology · 2010Article
- Vitamin D and bone health in adults with cystic fibrosis.Clinical endocrinology · 2008Article
- Chronic pediatric inflammatory diseases: effects on bone.Reviews in endocrine & metabolic disorders · 2008Review
- Vitamin D status in gastrointestinal and liver disease.Current opinion in gastroenterology · 2008Review
- Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series.Photodermatology, photoimmunology & photomedicine · 2007Article
- Update in cystic fibrosis 2005.American journal of respiratory and critical care medicine · 2006Review
- Vitamin D deficiency and chronic lung disease.Canadian respiratory journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
rationaleTreatment guidelines for vitamin D monitoring and supplementation in cystic fibrosis (CF) have recently been developed and published by a consensus committee, but have not been prospectively tested.
objectivesTo use these guidelines to determine the percentage of adults with CF requiring vitamin D repletion therapy and to evaluate the effectiveness of the currently recommended high-dose oral ergocalciferol repletion protocol.
methodsProspective study of clinical outcomes after therapy with the recommended vitamin D repletion algorithm.
resultsOf 134 adults with CF, 109 (81.3%) were found to have 25-hydroxyvitamin D (25-OHD) levels below the recommended 30 ng/ml. Sixty-six of these adults completed the recommended course of 400,000 IU of oral ergocalciferol over 2 months, and only five (8%) responded with correction of their serum 25-OHD to the goal of 30 ng/ml or greater (mean change, +0.3 ng/ml; from 18.8 to 19.1 ng/ml). In the 33 adults with CF who also completed the recommended second course of 800,000 IU of ergocalciferol over 2 months, none demonstrated correction of their deficiency (mean change, -1.2 ng/ml).
conclusionThe results of this study demonstrate that a majority of adults with CF have serum 25-OHD levels below 30 ng/ml, and the currently recommended ergocalciferol repletion regimen often does not fully correct vitamin D deficiency and may need to be revised to include even higher dosing of ergocalciferol. Further work is needed to establish the ideal 25-OHD level for maximizing calcium absorption and bone health in CF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.