Evidence map›Paper›PMID 15860711›Full record

SynthesisThorax2005

How should COPD patients exercise during respiratory rehabilitation? Comparison of exercise modalities and intensities to treat skeletal muscle dysfunction.

M A Puhan, H J Schünemann, M Frey, M Scharplatz, L M Bachmann

2 registry-linked trialsOpen access · bronzeAbstract readComparative StudyMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00925171 phase2unknown statusnot on this mapstarted 2009, after this paper: background citation

The Effects of Maintenance Schedules Following Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease

TypeinterventionalSponsorUniversity of East AngliaRan2009 to 2012Enrolled128ConditionsChronic Obstructive Pulmonary Disease, Pulmonary RehabilitationArmsPulmonary Intervention
NCT01150383 phase4completednot on this mapstarted 2010, after this paper: background citation

The Effect of Supplemental Oxygen During Physical Exercise Training on Exercise Capacity in COPD Patients.

TypeinterventionalSponsorParacelsus Medical UniversityRan2010 to 2013Enrolled50ConditionsChronic Obstructive Pulmonary DiseaseArmsPhysical exercise training with supplemental oxygen, Physical exercise training with "room air supplementation"
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Intensity of physical exercise and its effect on functional capacity in COPD: systematic review and meta-analysis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
    Pooled it
  6. Trial
  7. Trial
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  12. Obligatory neural feedback control of exercise cardiorespiratory function and performance.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. A little exercise.The journals of gerontology. Series A, Biological sciences and medical sciences · 2006
    Article
  18. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M A PuhanHorten Centre, University Hospital of Zurich, Switzerland. milo.puhan@evimed.ch
H J Schünemann
M Frey
M Scharplatz
L M Bachmann
University Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical exercise is an important component of respiratory rehabilitation because it reverses skeletal muscle dysfunction, a clinically important manifestation of COPD associated with reduced health-related quality of life (HRQL) and survival. However, there is controversy regarding the components of the optimal exercise protocol. A study was undertaken to systematically evaluate and summarise randomised controlled trials (RCTs) comparing different exercise protocols for COPD patients.

methodsSix electronic databases, congress proceedings and bibliographies of included studies were searched without imposing language restrictions. Two reviewers independently screened all records and extracted data on study samples, interventions and methodological characteristics of included studies.

resultsThe methodological quality of the 15 included RCTs was low to moderate. Strength exercise led to larger improvements of HRQL than endurance exercise (weighted mean difference for Chronic Respiratory Questionnaire 0.27, 95% CI 0.02 to 0.52). Interval exercise seems to be of similar effectiveness as continuous exercise, but there are few data on clinically relevant outcomes. One small RCT which included patients with mild COPD compared the effect of high and low intensity exercise (at 80% and 40% of the maximum exercise capacity, respectively) and found larger physiological training effects from high intensity exercise.

conclusionsStrength exercise should be routinely incorporated in respiratory rehabilitation. There is insufficient evidence to recommend high intensity exercise for COPD patients and investigators should conduct larger high quality trials to evaluate exercise intensities in patients with moderate to severe COPD.

Indexed as

Muscle, SkeletalExercise TherapyExercise ToleranceHealth StatusHumansMusculoskeletal DiseasesPulmonary Disease, Chronic ObstructiveQuality of LifeRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID15860711
PMCPMC1758898
OpenAlexW2111786661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.