ArticleDrug metabolism and disposition: the biological fate of chemicals2005
Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use.
Article in Drug metabolism and disposition: the biological fate of chemicals, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India.Clinical and translational science · 2020Trial
- Pharmacokinetics and Anti-Inflammatory Effects of Intramuscular Betamethasone in Exercised Thoroughbred Horses.Journal of veterinary pharmacology and therapeutics · 2026Article
- KECORT Study: An International e-Delphi Study on the Treatment of KEloids Using Intralesional CORTicosteroids in Clinical Practice.American journal of clinical dermatology · 2024Article
- Article
- Association between betamethasone levels and respiratory distress syndrome in preterm births: A prospective cohort study.Clinical and translational science · 2022Article
- Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques.Scientific reports · 2019Article
- Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.American journal of obstetrics and gynecology · 2018Article
- Quantitative determination of betamethasone sodium phosphate and betamethasone dipropionate in human plasma by UPLC-MS/MS and a bioequivalence study.Analytical methods : advancing methods and applications · 2016Article
- Controversy: antenatal steroids.Clinics in perinatology · 2011Review
- Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics.American journal of obstetrics and gynecology · 2010Article
- Betamethasone dose and formulation for induced lung maturation in fetal sheep.American journal of obstetrics and gynecology · 2009Article
- Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic.Clinical pharmacokinetics · 2009Article
- Article
- Ultra-sensitive quantification of paclitaxel using selective solid-phase extraction in conjunction with reversed-phase capillary liquid chromatography/tandem mass spectrometry.Journal of chromatography. A · 2008Article
- Betamethasone for lung maturation: testing dose and formulation in fetal sheep.American journal of obstetrics and gynecology · 2007Article
- Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical methods: assay validation and application to a pharmacokinetic study.Biomedical chromatography : BMC · 2007Article
- Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses.Obstetrics and gynecology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Maternal administration of betamethasone to enhance fetal lung maturation for women who threaten preterm labor is common clinical practice. However, recommendations regarding the choice of betamethasone formulations for perinatal use are vague. The disposition of betamethasone from two commonly used antenatal formulations is poorly understood. We therefore designed a study to capture the true pharmacokinetic profiles of betamethasone from these fast acting and dual-release formulations. Betamethasone in sheep plasma was measured by a newly designed, highly sensitive liquid chromatography/tandem mass spectrometry assay after intramuscular injection (n = 4) of 0.25 mg/kg betamethasone phosphate and 0.5 mg/kg betamethasone phosphate/acetate formulations. Compartmental modeling was performed using the ADAPT II program. Betamethasone pharmacokinetics could be captured for 24 h for the phosphate and for 5 days for the phosphate/acetate formulations. The phosphate formulation profile had the appearance of a traditional Bateman function with a terminal half-life of 4 h, whereas the phosphate/acetate formulation produced a biexponential decline with a terminal half-life of 14 h. The latter is much longer than is commonly reported and has been missed in the literature due to assay limitations. Extrapolations to humans indicate that although both formulations might have similar therapeutic indices, the dual formulation might be associated with a lower safety profile. In light of this newly identified long terminal half-life for the betamethasone dual formulation, dosing practices for betamethasone in pregnancy need to be reassessed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.