Trial reportThe Journal of physiology2005
Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans.
Trial report in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 257 citations in OpenAlex.
- Impact of Pre-exercise Hypohydration on Aerobic Exercise Performance, Peak Oxygen Consumption and Oxygen Consumption at Lactate Threshold: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Age differences in physiological responses to self-paced and incremental [Formula: see text] testing.European journal of applied physiology · 2017Trial
- RhEPO improves time to exhaustion by non-hematopoietic factors in humans.European journal of applied physiology · 2016Trial
- Effects of hypoxia on diaphragmatic fatigue in highly trained athletes.The Journal of physiology · 2007Trial
- The impact of biological sex and stroke volume constituents on heterogeneity in theExperimental physiology · 2026Article
- Skeletal muscle proteomics links mitochondrial abundance with peak fat oxidation in physically active young males.The Journal of physiology · 2026Article
- Optimizing the predictive validity of NIRS kinetic profiles to predict aerobic capacity from a resting skeletal muscle occlusion test.Experimental physiology · 2026Article
- The efficacy and physiological bases of small muscle mass exercise in health and disease.Experimental physiology · 2026Review
- Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.Sports medicine (Auckland, N.Z.) · 2026Article
- Increases in skin perfusion and blood oxygen in the non-exercising human limbs during exercise in the heat: Implications for control of circulation.Experimental physiology · 2025Article
- A critical assessment of sympathetic restraint in submaximal exercise: Implications for integrated cardiovascular circuit control in exercise.Experimental physiology · 2025Review
- The heart, a secondary organ in the control of blood circulation.Experimental physiology · 2025Review
- Limited matching of the cardiac output response to the peripheral demand of heat stress and exercise.Experimental physiology · 2025Article
- Reliability of hemodynamic parameters measured by bioimpedance cardiography at different intensities during incremental exercise testing.Frontiers in cardiovascular medicine · 2025Article
- On the mechanisms of stress-induced human spleen contraction: training for a higher blood oxygen-carrying capacity.European journal of applied physiology · 2024Review
- A century of exercise physiology: key concepts in neural control of the circulation.European journal of applied physiology · 2024Review
- The Influence of Cold Therapy on the Physical Working Capacity at the Electromyographic Threshold for Consecutive Exercise Sessions.Bioengineering (Basel, Switzerland) · 2024Article
- The cardiovascular changes underlying a low cardiac output with exercise in patients with type 2 diabetes mellitus.Frontiers in physiology · 2024Review
- The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation.PloS one · 2024Article
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reductions in systemic and locomotor limb muscle blood flow and O2 delivery limit aerobic capacity in humans. To examine whether O2 delivery limits both aerobic power and capacity, we first measured systemic haemodynamics, O2 transport and O2 uptake during incremental and constant (372 +/- 11 W; 85% of peak power; mean +/- S.E.M.) cycling exercise to exhaustion (n = 8) and then measured systemic and leg haemodynamics and during incremental cycling and knee-extensor exercise in male subjects (n = 10). During incremental cycling, cardiac output and systemic O2 delivery increased linearly to 80% of peak power (r2 = 0.998, P < 0.001) and then plateaued in parallel to a decline in stroke volume (SV) and an increase in central venous and mean arterial pressures (P < 0.05). In contrast, heart rate and increased linearly until exhaustion (r2 = 0.993; P < 0.001) accompanying a rise in systemic O2 extraction to 84 +/- 2%. In the exercising legs, blood flow and O2 delivery levelled off at 73-88% of peak power, blunting leg per unit of work despite increasing O2 extraction. When blood flow increased linearly during one-legged knee-extensor exercise, per unit of work was unaltered on fatigue. During constant cycling, , SV, systemic O2 delivery and reached maximal values within approximately 5 min, but dropped before exhaustion (P < 0.05) despite increasing or stable central venous and mean arterial pressures. In both types of maximal cycling, the impaired systemic O2 delivery was due to the decline or plateau in because arterial O2 content continued to increase. These results indicate that an inability of the circulatory system to sustain a linear increase in O2 delivery to the locomotor muscles restrains aerobic power. The similar impairment in SV and O2 delivery during incremental and constant load cycling provides evidence for a central limitation to aerobic power and capacity in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.