Trial reportThe Journal of physiology2005
Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium.
Trial report in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 141 citations in OpenAlex.
- Extracellular Buffering Supplements to Improve Exercise Capacity and Performance: A Comprehensive Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Acute sodium bicarbonate supplementation reduces the increase in markers of acute kidney injury during physical work in the heat.European journal of applied physiology · 2025Trial
- Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?PloS one · 2021Trial
- Enhanced 400-m sprint performance in moderately trained participants by a 4-day alkalizing diet: a counterbalanced, randomized controlled trial.Journal of the International Society of Sports Nutrition · 2018Trial
- Biochemical responses and physical performance during high-intensity resistance circuit training in hypoxia and normoxia.European journal of applied physiology · 2017Trial
- Effects of pre-exercise alkalosis on the decrease in VO2 at the end of all-out exercise.European journal of applied physiology · 2016Trial
- Impact of acute sodium citrate ingestion on endurance running performance in a warm environment.European journal of applied physiology · 2015Trial
- Sodium bicarbonate intake improves high-intensity intermittent exercise performance in trained young men.Journal of the International Society of Sports Nutrition · 2015Trial
- Bicarbonate ingestion has no ergogenic effect on consecutive all out sprint tests in BMX elite cyclists.European journal of applied physiology · 2011Trial
- High-intensity exercise decreases muscle buffer capacity via a decrease in protein buffering in human skeletal muscle.Pflugers Archiv : European journal of physiology · 2009Trial
- Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans.The Journal of physiology · 2008Trial
- N-acetylcysteine attenuates the decline in muscle Na+,K+-pump activity and delays fatigue during prolonged exercise in humans.The Journal of physiology · 2006Trial
- The impact of intradialytic cycling on temporal changes in muscle sodium during hemodialysis.Clinical kidney journal · 2026Article
- Carbon Dioxide Inhalation-Risks for Health or Opportunity for Physical Fitness Development?Journal of clinical medicine · 2026Review
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- The effects of sodium hydrogen carbonate ingestion during the recovery period between two 200-m front-crawl time trials.European journal of applied physiology · 2024Article
- A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle NaEuropean journal of applied physiology · 2024Review
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Review
- Transcutaneous delivery of sodium bicarbonate increases intramuscular pH.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle releases potassium during activity. Interstitial potassium accumulation is important for muscle function and the development of fatigue resulting from exercise. In the present study we used sodium citrate ingestion as a tool to investigate the relationship between interstitial H+ concentration and K+ accumulation during exercise. Seven healthy subjects performed one-legged knee-extensor exercise on two separate days with and without sodium citrate ingestion. Interstitial H+ and K+ concentrations were measured with the microdialysis technique. Citrate ingestion reduced the plasma H+ concentration and increased the plasma HCO3- concentration. Citrate had no effect on interstitial H+ at rest. The increase in interstitial H+ concentration during intense exercise was significantly lower (P < 0.05) with citrate ingestion compared to control (peak interstitial H+ concentration 79 versus 131 nM). After 3 min of exercise interstitial K+ concentration was reduced (P < 0.05) in the citrate (alkalosis) compared to the control experiment (8.0 +/- 0.9 versus 11.0 +/- 2 mM) and interstitial K+ concentration remained lower during the rest of the exercise period. The present study demonstrated a link between interstitial H+ and K+ accumulation, which may be through the ATP-sensitive K+ channels (KATP channels), which are sensitive to changes in H+.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.