ArticleMammalian genome : official journal of the International Mammalian Genome Society2005
Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Impact ofCancers · 2024Article
- Generating Mitochondrial-Nuclear Exchange (MNX) Mice to Identify Mitochondrial Determinants of Cancer Metastasis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The genomic landscape of metastasis in treatment-naïve breast cancer models.PLoS genetics · 2020Article
- Genetic insights into the morass of metastatic heterogeneity.Nature reviews. Cancer · 2018Review
- Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver-Dependent Manner.Cancer research · 2017Article
- An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.PLoS genetics · 2016Article
- Angiogenesis QTL on Mouse Chromosome 8 Colocalizes with Differential β-Defensin Expression.Journal of biomolecular techniques : JBT · 2015Article
- An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease.Genome research · 2014Article
- Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation.Clinical & experimental metastasis · 2013Article
- The long path from QTL to gene.PLoS genetics · 2012Article
- Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity.PLoS genetics · 2012Article
- Bromodomain-Containing Protein 4: A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix.International journal of breast cancer · 2012Article
- Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2009Review
- Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis.Cancer science · 2009Review
- Mouse modifier genes in mammary tumorigenesis and metastasis.Journal of mammary gland biology and neoplasia · 2008Review
- Bromodomain 4 activation predicts breast cancer survival.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models.Breast cancer research : BCR · 2008Review
- The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival.Clinical & experimental metastasis · 2008Article
- Mammary cancer susceptibility: human genes and rodent models.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tumor progression, the growth and dissemination of primary tumor to secondary sites, is of critical clinical importance since the vast majority of patients succumb to metastatic disease rather than to the primary tumor. Many factors are likely to influence this process, including the primary oncogenic events, environmental exposures and stress and progressive stochastic mutations. Previously, our laboratory demonstrated that an additional factor, the genetic background on which tumors arose, had a significant effect on metastatic efficiency. Using a highly metastatic transgene-induced mammary tumor model, a locus modulating metastatic efficiency, Mtes1, was localized on proximal mouse Chromosome 19. In addition, a number of additional suggestive loci were observed on several other chromosomes. To confirm the presence of these additional loci before initiating cloning strategies, chromosomal substitution strains have been constructed and assayed for modification of the cancer phenotypes. Using the chromosomal substitution strains, an additional modifier modulating tumor latency was confirmed, as well as three new modifier genes that alter the kinetics of tumor progression. Identification and analysis of these loci will likely present interesting and novel information about cancer heterogeneity in the human population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.